Publication: Vitamin D regulation of adipogenesis and adipose tissue functions
Issued Date
2020-12-01
Resource Type
ISSN
20056168
19761457
19761457
Other identifier(s)
2-s2.0-85097389431
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Nutrition Research and Practice. Vol.14, No.6 (2020), 553-567
Suggested Citation
Hataikarn Nimitphong, Eunmi Park, Mi Jeong Lee Vitamin D regulation of adipogenesis and adipose tissue functions. Nutrition Research and Practice. Vol.14, No.6 (2020), 553-567. doi:10.4162/nrp.2020.14.6.553 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/60343
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Title
Vitamin D regulation of adipogenesis and adipose tissue functions
Author(s)
Abstract
© 2020 The Korean Nutrition Society and the Korean Society of Community Nutrition. Vitamin D insufficiency is associated with obesity and its related metabolic diseases. Adipose tissues store and metabolize vitamin D and expression levels of vitamin D metabolizing enzymes are known to be altered in obesity. Sequestration of vitamin D in large amount of adipose tissues and low vitamin D metabolism may contribute to the vitamin D inadequacy in obesity. Vitamin D receptor is expressed in adipose tissues and vitamin D regulates multiple aspects of adipose biology including adipogenesis as well as metabolic and endocrine function of adipose tissues that can contribute to the high risk of metabolic diseases in vitamin D insufficiency. We will review current understanding of vitamin D regulation of adipose biology focusing on vitamin D modulation of adiposity and adipose tissue functions as well as the molecular mechanisms through which vitamin D regulates adipose biology. The effects of supplementation or maintenance of vitamin D on obesity and metabolic diseases are also discussed.