Publication: Blood-brain barrier function and biomarkers of central nervous system injury in rickettsial versus other neurological infections in Laos
2
Issued Date
2015-01-01
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ISSN
00029637
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2-s2.0-84939244128
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Mahidol University
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SCOPUS
Bibliographic Citation
American Journal of Tropical Medicine and Hygiene. Vol.93, No.2 (2015), 232-237
Suggested Citation
Sabine Dittrich, Piyanate Sunyakumthorn, Sayaphet Rattanavong, Rattanaphone Phetsouvanh, Phonepasith Panyanivong, Amphonsavanh Sengduangphachanh, Phonelavanh Phouminh, Tippawan Anantatat, Anisone Chanthongthip, Sue J. Lee, Audrey Dubot-Péres, Nicholas P.J. Day, Daniel H. Paris, Paul N. Newton, Gareth D.H. Turner Blood-brain barrier function and biomarkers of central nervous system injury in rickettsial versus other neurological infections in Laos. American Journal of Tropical Medicine and Hygiene. Vol.93, No.2 (2015), 232-237. doi:10.4269/ajtmh.15-0119 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/36148
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Title
Blood-brain barrier function and biomarkers of central nervous system injury in rickettsial versus other neurological infections in Laos
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Abstract
© 2015 by The American Society of Tropical Medicine and Hygiene. Blood-brain barrier (BBB) function and cerebrospinal fluid (CSF) biomarkers were measured in patients admitted to hospital with severe neurological infections in the Lao People's Democratic Republic (N = 66), including bacterial meningitis (BM; N = 9) or tuberculosis meningitis (TBM; N = 11), Japanese encephalitis virus (JEV; N = 25), and rickettsial infections (N = 21) including murine and scrub typhus patients. The albumin index (AI) and glial fibrillary acidic protein (GFAP) levels were significantly higher in BM and TBM than other diseases but were also raised in individual rickettsial patients. Total tau protein was significantly raised in the CSF of JEV patients. No differences were found between clinical or neurological symptoms, AI, or biomarker levels that allowed distinction between severe neurological involvement by Orientia tsutsugamushi compared with Rickettsia species.