Publication: Increased Burden of Concordant and Sequential Anogenital Human Papillomavirus Infections Among Asian Young Adult Women With Perinatally Acquired HIV Compared With HIV-Negative Peers
Issued Date
2021-03-01
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15374521
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2-s2.0-85102090799
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Mahidol University
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SCOPUS
Bibliographic Citation
Sexually transmitted diseases. Vol.48, No.3 (2021), 200-205
Suggested Citation
Annette H. Sohn, Amphan Chalermchockcharoenkit, Sirinya Teeraananchai, Rawiwan Hansudewechakul, Sivaporn Gatechompol, Kulkanya Chokephaibulkit, Hanh Le Dung Dang, Dan Ngoc Hanh Tran, Jullapong Achalapong, Nipat Teeratakulpisarn, Manopchai Thamkhantho, Nittaya Phanuphak, Jintanat Ananworanich, Peter Reiss, Stephen J. Kerr Increased Burden of Concordant and Sequential Anogenital Human Papillomavirus Infections Among Asian Young Adult Women With Perinatally Acquired HIV Compared With HIV-Negative Peers. Sexually transmitted diseases. Vol.48, No.3 (2021), 200-205. doi:10.1097/OLQ.0000000000001294 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/78392
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Title
Increased Burden of Concordant and Sequential Anogenital Human Papillomavirus Infections Among Asian Young Adult Women With Perinatally Acquired HIV Compared With HIV-Negative Peers
Author(s)
Annette H. Sohn
Amphan Chalermchockcharoenkit
Sirinya Teeraananchai
Rawiwan Hansudewechakul
Sivaporn Gatechompol
Kulkanya Chokephaibulkit
Hanh Le Dung Dang
Dan Ngoc Hanh Tran
Jullapong Achalapong
Nipat Teeratakulpisarn
Manopchai Thamkhantho
Nittaya Phanuphak
Jintanat Ananworanich
Peter Reiss
Stephen J. Kerr
Amphan Chalermchockcharoenkit
Sirinya Teeraananchai
Rawiwan Hansudewechakul
Sivaporn Gatechompol
Kulkanya Chokephaibulkit
Hanh Le Dung Dang
Dan Ngoc Hanh Tran
Jullapong Achalapong
Nipat Teeratakulpisarn
Manopchai Thamkhantho
Nittaya Phanuphak
Jintanat Ananworanich
Peter Reiss
Stephen J. Kerr
Abstract
BACKGROUND: Youth with perinatally acquired HIV (YPHIV) are at higher risk for anogenital human papillomavirus (HPV) infection. METHODS: We enrolled a cohort of YPHIV and HIV-negative youth in Thailand and Vietnam, matched by age and lifetime sex partners, and followed them up for 144 weeks (to 2017). Participants had annual pelvic examinations with samples taken for HPV genotyping. Concordant infection was simultaneous HPV detection in multiple anogenital compartments (cervical, vaginal, anal); sequential infection was when the same type was found in successive compartments (cervicovaginal to/from anal). Generalized estimating equations were used to assess factors associated with concordant infection, and Cox regression was used to assess factors associated with sequential infection. RESULTS: A total of 93 YPHIV and 99 HIV-negative women were enrolled, with a median age of 19 years (interquartile range, 18-20 years). High-risk anogenital HPV infection was ever detected in 76 (82%) YPHIV and 66 (67%) HIV-negative youth during follow-up. Concordant anogenital high-risk HPV infection was found in 62 (66%) YPHIV versus 44 (34%) HIV-negative youth. Sequential cervicovaginal to anal high-risk HPV infection occurred in 20 YPHIV versus 5 HIV-negative youth, with an incidence rate of 9.76 (6.30-15.13) versus 2.24 (0.93-5.38) per 100 person-years. Anal to cervicovaginal infection occurred in 4 YPHIV versus 0 HIV-negative women, with an incidence rate of 1.78 (0.67-4.75) per 100 person-years. Perinatally acquired HIV was the one factor independently associated with both concordant and sequential high-risk HPV infection. CONCLUSIONS: Children and adolescents with perinatally acquired HIV should be prioritized for HPV vaccination, and cervical cancer screening should be part of routine HIV care for sexually active YPHIV.