Publication: High vitamin D status in younger individuals is associated with low circulatingthyrotropin
Issued Date
2013-01-01
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ISSN
15579077
10507256
10507256
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2-s2.0-84872075050
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Mahidol University
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SCOPUS
Bibliographic Citation
Thyroid. Vol.23, No.1 (2013), 25-30
Suggested Citation
La Or Chailurkit, Wichai Aekplakorn, Boonsong Ongphiphadhanakul High vitamin D status in younger individuals is associated with low circulatingthyrotropin. Thyroid. Vol.23, No.1 (2013), 25-30. doi:10.1089/thy.2012.0001 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/31396
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Title
High vitamin D status in younger individuals is associated with low circulatingthyrotropin
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Abstract
Background: Vitamin D is an immunomodulator and may affect autoimmune thyroid diseases. Vitamin D has also been shown to influence thyrocytes directly by attenuating thyrotropin (TSH)-stimulated iodide uptake and cell growth. However, it is unclear how vitamin D status is related to TSH at the population level. The goal of the present study was to investigate the relationship between vitamin D status and TSH levels according to thyroid autoantibodies in a population-based health survey in Thailand. Methods: A total of 2582 adults, aged 15-98 years, were randomly selected according to the geographical region from the Thailand 4th National Health Examination Survey sample. By study design, the sexes were equally represented. Serum levels of 25-hydroxyvitamin D [25(OH)D], TSH, the thyroid peroxidase antibody (TPOAb), and the thyroglobulin antibody (TgAb) were measured in all subjects. Results: The mean age was 55.0±0.4 (SE) years. In subjects positive for serum TgAb, serum TSH levels were higher, whereas total serum 25(OH)D levels were lower. In addition, the prevalence of vitamin D insufficiency in TgAb-positive subjects was significantly higher than that observed in TPOAb- and TgAb-negative subjects, whether based on cutoff values of 20 or 30 ng/mL: 8.3% vs. 5.6%, p<0.05; or 47.6% vs. 42.0%, p<0.05, respectively. However, vitamin D status was not associated with positive TPOAb and/or TgAb after controlling for sex and age. To explore the probable interaction between vitamin D status and age on serum TSH, analyses were performed according to age tertiles; it was found that higher 25(OH)D levels were independently associated with lower TSH, but only in subjects in the lowest age tertile. Conclusions: This population-based study showed that high vitamin D status in younger individuals is associated with low circulating TSH. © Copyright 2013, Mary Ann Liebert, Inc.