Publication:
Efficacy of artemisinin-based and quinine-based treatments for uncomplicated falciparum malaria in pregnancy: A protocol for systematic review and individual patient data (IPD) meta-analysis

dc.contributor.authorMakoto Saitoen_US
dc.contributor.authorRashid Mansooren_US
dc.contributor.authorKalynn Kennonen_US
dc.contributor.authorRose McGreadyen_US
dc.contributor.authorFrançois Nostenen_US
dc.contributor.authorPhilippe J. Guérinen_US
dc.contributor.authorKasia Stepniewskaen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherNuffield Department of Clinical Medicineen_US
dc.contributor.otherWorldWide Antimalarial Resistance Network (WWARN)en_US
dc.date.accessioned2020-01-27T09:38:34Z
dc.date.available2020-01-27T09:38:34Z
dc.date.issued2019-08-01en_US
dc.description.abstract© Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY. Published by BMJ. Introduction Pregnant women are more vulnerable to malaria leading to adverse impact on both mothers and fetuses. However, knowledge on the efficacy and safety of antimalarials in pregnancy is limited by the paucity of randomised control trials and the lack of standardised protocols in this special subpopulation. Pooling individual patient data (IPD) for meta-analysis could address in part these limitations to summarise accurately the currently available evidence on treatment efficacy and risk factors for treatment failure. Methods and analysis To assess the treatment efficacy of artemisinin-based and quinine-based treatments for uncomplicated falciparum malaria in pregnancy, seven databases (Medline, Embase, Global Health, Cochrane Library, Scopus, Web of Science and Literatura Latino Americana em Ciências da Saúde) and two clinical trial registries (International Clinical Trials Registry Platform and ClinicalTrial.gov) were searched. Both interventional and observational cohort studies following up for at least 28 days will be included. IPD of the identified eligible published or unpublished studies will be sought by inviting principal investigators. Raw IPD will be shared through the web-based secure platform developed by the WorldWide Antimalarial Resistance Network using the established methodology. The primary objective is to compare the risk of PCR-corrected treatment failure among different treatments and to find the risk factors. One-stage IPD meta-analysis by Cox model with shared frailty will be conducted. A risk of bias assessment will be conducted to address the impact of unshared potential data and of the quality of individual studies. Potential limitations include difficulty in acquiring the IPD and heterogeneity of the study designs due to the lack of standard. Ethics and dissemination This IPD meta-analysis consists of secondary analyses of existing anonymous data and meets the criteria for waiver of ethics review by the Oxford Tropical Research Ethics Committee. The results of this IPD meta-analysis will be disseminated through open-access publications at peer-reviewed journals. The study results will lead to a better understanding of malaria treatment in pregnancy, which can be used for clinical decision-making and conducting further studies. PROSPERO registration number CRD42018104013.en_US
dc.identifier.citationBMJ Open. Vol.9, No.8 (2019)en_US
dc.identifier.doi10.1136/bmjopen-2018-027503en_US
dc.identifier.issn20446055en_US
dc.identifier.other2-s2.0-85071269536en_US
dc.identifier.urihttps://repository.li.mahidol.ac.th/handle/20.500.14594/51506
dc.rightsMahidol Universityen_US
dc.rights.holderSCOPUSen_US
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85071269536&origin=inwarden_US
dc.subjectMedicineen_US
dc.titleEfficacy of artemisinin-based and quinine-based treatments for uncomplicated falciparum malaria in pregnancy: A protocol for systematic review and individual patient data (IPD) meta-analysisen_US
dc.typeArticleen_US
dspace.entity.typePublication
mu.datasource.scopushttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85071269536&origin=inwarden_US

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