Publication:
Vicinal dianions of diethyl α-aroylsuccinates: A general synthetic route to α-aroyl- and α-arylidene-γ-butyrolactones

Issued Date

2003-08-25

Resource Type

Article

ISSN

00404039

DOI

10.1016/S0040-4039(03)01622-8

Other identifier(s)

2-s2.0-0043172234

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

Tetrahedron Letters. Vol.44, No.35 (2003), 6717-6720

Suggested Citation

Manat Pohmakotr, Laddawan Sampaongoen, Arisara Issaree, Patoomratana Tuchinda, Vichai Reutrakul Vicinal dianions of diethyl α-aroylsuccinates: A general synthetic route to α-aroyl- and α-arylidene-γ-butyrolactones. Tetrahedron Letters. Vol.44, No.35 (2003), 6717-6720. doi:10.1016/S0040-4039(03)01622-8 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/20699

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Title

Vicinal dianions of diethyl α-aroylsuccinates: A general synthetic route to α-aroyl- and α-arylidene-γ-butyrolactones

Author(s)

Manat Pohmakotr
 Laddawan Sampaongoen
 Arisara Issaree
 Patoomratana Tuchinda
 Vichai Reutrakul

Other Contributor(s)

Mahidol University

Abstract

Vicinal dianions derived from diethyl α-aroylsuccinates were found to react with carbonyl compounds β-regioselectively to afford α-aroyl-γ-butyrolactones, which were converted into α-arylidene-γ-butyrolactones by reduction with H2/Pd-C followed by elimination employing methanesulfonyl chloride in pyridine. The method provides a general and convenient route to α-aroyl- and α-arylidene-γ-butyrolactones. © 2003 Elsevier Ltd. All rights reserved.

Keyword(s)

Biochemistry, Genetics and Molecular Biology
 Chemistry
 Pharmacology, Toxicology and Pharmaceutics

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URI

https://repository.li.mahidol.ac.th/handle/20.500.14594/20699

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Scopus 2001-2005