Publication: Biomarkers of cobalamin (vitamin B12) deficiency and its application
Issued Date
2011-03-01
Resource Type
ISSN
17604788
12797707
12797707
Other identifier(s)
2-s2.0-79954420646
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of Nutrition, Health and Aging. Vol.15, No.3 (2011), 227-231
Suggested Citation
W. Chatthanawaree Biomarkers of cobalamin (vitamin B12) deficiency and its application. Journal of Nutrition, Health and Aging. Vol.15, No.3 (2011), 227-231. doi:10.1007/s12603-010-0280-x Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/12596
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Title
Biomarkers of cobalamin (vitamin B12) deficiency and its application
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Abstract
Cobalamin (vitamin B12) deficiency in the elderly is an under recognized problem in daily clinical practice. It seems to be important because the deficiency of this vitamin can lead to irreversible neurological damage, anemia, osteoporosis, and cerebrovascular and cardiovascular diseases. Some clinical abnormalities that we thought were related to the normal aging changes may actually be caused by cobalamin deficiency, such as lack of ankle jerk reflex. The prevalence of cobalamin deficiency increases with age (ranges from 0.6% to 46% depending on the population studies and criteria for diagnosis). Other than clinical manifestations, there are some biomarkers for detection of cobalamin deficiency: the red blood cell mean corpuscular volume (MCV); serum cobalamin level; plasma holotranscobalamin; serum methylmalonic acid (MMA) levels and serum homocysteine levels. The interpretation and the application of these biomarkers are here presented. © 2011 Serdi and Springer Verlag France.