Publication: Myofibroblasts and inflammatory cells as players of cardiac fibrosis
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Issued Date
2016-08-01
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ISSN
19763786
02536269
02536269
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2-s2.0-84981485012
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Mahidol University
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SCOPUS
Bibliographic Citation
Archives of Pharmacal Research. Vol.39, No.8 (2016), 1100-1113
Suggested Citation
Hitoshi Kurose, Supachoke Mangmool Myofibroblasts and inflammatory cells as players of cardiac fibrosis. Archives of Pharmacal Research. Vol.39, No.8 (2016), 1100-1113. doi:10.1007/s12272-016-0809-6 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/42981
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Title
Myofibroblasts and inflammatory cells as players of cardiac fibrosis
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Abstract
© 2016, The Pharmaceutical Society of Korea. On myocardial infarction, many cells are injured or died owing to arterial occlusion. Intracellular molecules released from injured or dead cells initiate inflammatory responses that play important roles in cardiac remodeling including fibrosis. Fibrosis is an excess accumulation of extracellular collagen. Currently, drugs used to treat cardiac fibrosis are not commercially available. Myofibroblasts are responsible for the production and secretion of collagen. Infiltrating inflammatory cells interact with fibroblasts or other cells and promote myofibroblast formation. Inflammatory cells also modulate the activities of myofibroblasts. Regulation of collagen production is critical for modulating the progression of fibrosis. Hence, the manipulation of activities of inflammatory cells and myofibroblasts will provide promising therapeutic targets for treatment of cardiac fibrosis.