Publication: Reference value for urinary deoxypyridinoline as a specific marker for measuring bone resorption in Thais
Issued Date
1999-01-01
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ISSN
01252208
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2-s2.0-0042731721
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of the Medical Association of Thailand. Vol.82, No.11 (1999), 1135-1140
Suggested Citation
Phannee Pidetcha, Kingkaew Patrakarn, Somsak Fongsupa, Srisanit Intramanee, Pairoj Leelahakul Reference value for urinary deoxypyridinoline as a specific marker for measuring bone resorption in Thais. Journal of the Medical Association of Thailand. Vol.82, No.11 (1999), 1135-1140. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/25714
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Title
Reference value for urinary deoxypyridinoline as a specific marker for measuring bone resorption in Thais
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Abstract
In the next century, the increasing number of elderly and rising healthcare costs will bring with it metabolic bone problems, particularly osteoporosis. Deoxypyridinoline: Dpd in urine is a sensitive and specific marker for screening and monitoring of bone resorption in a variety of diseases affecting bone turnover and in risk groups especially in the postmenopause. The reference value among aging (21-60 years) of a healthy well defined group was studied by collecting the urine between 700-1000 hours and using the ELISA technique to determine the level of Dpd. The reference value of Dpd in 113 males and 298 females 1.3-6.5 and 1.5-6.9 nm Dpd/nm Creatinine respectively. The level of Dpd in females was significantly higher than in males at p<0.028. However, the average value of deoxypyridinoline in postmenopause was higher than premenopause but not different at p = 0.05. There are many factors which influence the results so the overall reference value is only a guideline for screening in bone resorption.