Publication: Chronic inflammation and cytokines in the tumor microenvironment
Issued Date
2014-01-01
Resource Type
ISSN
23147156
23148861
23148861
Other identifier(s)
2-s2.0-84901767734
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of Immunology Research. Vol.2014, (2014)
Suggested Citation
Glauben Landskron, Marjorie De La Fuente, Peti Thuwajit, Chanitra Thuwajit, Marcela A. Hermoso Chronic inflammation and cytokines in the tumor microenvironment. Journal of Immunology Research. Vol.2014, (2014). doi:10.1155/2014/149185 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/34071
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Title
Chronic inflammation and cytokines in the tumor microenvironment
Other Contributor(s)
Abstract
Acute inflammation is a response to an alteration induced by a pathogen or a physical or chemical insult, which functions to eliminate the source of the damage and restore homeostasis to the affected tissue. However, chronic inflammation triggers cellular events that can promote malignant transformation of cells and carcinogenesis. Several inflammatory mediators, such as TNF-α, IL-6, TGF-β, and IL-10, have been shown to participate in both the initiation and progression of cancer. In this review, we explore the role of these cytokines in important events of carcinogenesis, such as their capacity to generate reactive oxygen and nitrogen species, their potential mutagenic effect, and their involvement in mechanisms for epithelial mesenchymal transition, angiogenesis, and metastasis. Finally, we will provide an in-depth analysis of the participation of these cytokines in two types of cancer attributable to chronic inflammatory disease: colitis-associated colorectal cancer and cholangiocarcinoma. © 2014 Glauben Landskron et al.