Publication: Antioxidant, cytotoxic and á-glucosidase inhibitory activities of compounds isolated from the twig extracts of maclura fruticosa
Issued Date
2017-01-01
Resource Type
ISSN
15559475
1934578X
1934578X
Other identifier(s)
2-s2.0-85026481448
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Mahidol University
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SCOPUS
Bibliographic Citation
Natural Product Communications. Vol.12, No.7 (2017), 1073-1076
Suggested Citation
Isaraporn Polbuppha, Wisanu Maneerat, Tawanun Sripisut, Thunwadee Limtharakul, Sarot Cheenpracha, Stephen G. Pyne, Chatchai Muanprasat, Sawinee Seemakhan, Suparerk Borwornpinyo, Surat Laphookhieo Antioxidant, cytotoxic and á-glucosidase inhibitory activities of compounds isolated from the twig extracts of maclura fruticosa. Natural Product Communications. Vol.12, No.7 (2017), 1073-1076. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/41608
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Title
Antioxidant, cytotoxic and á-glucosidase inhibitory activities of compounds isolated from the twig extracts of maclura fruticosa
Abstract
The first phytochemical investigation of the twig extracts of Maclura fruticosa led to the isolation and identification of a new xanthone, maclurafruticosone (1), together with 14 known compounds (2-15). All compounds were elucidated using spectroscopic methods as well as through comparisons made with data reported in the literature. Some isolated compounds were evaluated for their antioxidant, α-glucosidase inhibitory and cytotoxic activities. Compound 4, 6 and 7 showed significant antioxidant activity against DPPH radicals with IC50values ranging from 7.45-V16.12 μM. Compound 4 also exhibited potent activity against ABTS.,h+scavenging activity with an IC50value of 0.55 iÓ 0.01 £gM which was better than positive control (ascorbic acid, IC502.35-0.17 μM). Compound 12 showed significant α-glucosidase inhibitory activity with an IC50value of 0.02-0.37 mM. Compounds 5, 6 and 12 showed weak cytotoxic activities against a colon cancer cell line with IC50values ranging from 22.35-47.62 μM.