Publication: Urinary antibiotic activity in paediatric patients attending an outpatient department in north-western Cambodia
Issued Date
2015-01-01
Resource Type
ISSN
13653156
13602276
13602276
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2-s2.0-84913612649
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Mahidol University
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SCOPUS
Bibliographic Citation
Tropical Medicine and International Health. Vol.20, No.1 (2015), 24-28
Suggested Citation
Katherine R.W. Emary, Michael J. Carter, Sreymom Pol, Soeng Sona, Varun Kumar, Nicholas P.J. Day, Christopher M. Parry, Catrin E. Moore Urinary antibiotic activity in paediatric patients attending an outpatient department in north-western Cambodia. Tropical Medicine and International Health. Vol.20, No.1 (2015), 24-28. doi:10.1111/tmi.12398 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/36175
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Title
Urinary antibiotic activity in paediatric patients attending an outpatient department in north-western Cambodia
Abstract
© 2014 The Authors. Tropical Medicine & International Health Published by John Wiley & Sons Ltd. Objective: Antibiotic resistance is a prominent public and global health concern. We investigated antibiotic use in children by determining the proportion of unselected children with antibacterial activity in their urine attending a paediatric outpatient department in Siem Reap, Cambodia. Methods: Caregiver reports of medication history and presence of possible infection symptoms were collected in addition to urine samples. Urine antibiotic activity was estimated by exposing bacteria to urine specimens, including assessment against multiresistant bacteria previously isolated from patients in the hospital (a methicillin-resistant Staphylococcus aureus (MRSA), a multiresistant Salmonella typhi and an extended-spectrum β-lactamase (ESBL)-producing Escherichia coli isolate). Results: Medication information and urine were collected from 775 children. Caregivers reported medication use in 69.0% of children in the preceding 48 h. 31.7% samples showed antibacterial activity; 16.3% showed activity against a local multiresistant organism. No specimens demonstrated activity against an ESBL-producing E. coli. Conclusions: Antibiotics are widely used in the community setting in Cambodia. Parents are often ill-informed about drugs given to treat their children. Increasing the regulation and training of private pharmacies in Cambodia may be necessary. Regional surveillance of antibiotic use and resistance is also essential in devising preventive strategies against further development of antibiotic resistance, which would have both local and global consequences.