Publication:
Autophagy and p62/sequestosome 1 generate neo-antimicrobial peptides (cryptides) from cytosolic proteins

Issued Date

2011-01-01

Resource Type

Short Survey

ISSN

15548635
15548627

DOI

10.4161/auto.7.3.14500

Other identifier(s)

2-s2.0-79952333943

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

Autophagy. Vol.7, No.3 (2011), 336-337

Suggested Citation

Marisa Ponpuak, Vojo Deretic Autophagy and p62/sequestosome 1 generate neo-antimicrobial peptides (cryptides) from cytosolic proteins. Autophagy. Vol.7, No.3 (2011), 336-337. doi:10.4161/auto.7.3.14500 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/11613

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Title

Autophagy and p62/sequestosome 1 generate neo-antimicrobial peptides (cryptides) from cytosolic proteins

Author(s)

Marisa Ponpuak
 Vojo Deretic

Other Contributor(s)

Mahidol University
 University of New Mexico School of Medicine

Abstract

In a manifestation of the immunological autophagy termed xenophagy, autophagic adapter proteins such as p62 and NDP52 directly capture microbes for delivery to autophagosomal organelles where they are eliminated. In a mirror image phenomenon, which is also an immunological variant of the process termed decryption, p62 and autophagy contribute to the elimination of Mycobacterium tuberculosis. During decryption, p62 sequesters cytosolic proteins into autophagosomes where they are proteolytically converted into peptides termed cryptides. A subset of cryptides possesses antimicrobial peptide properties exhibited upon their delivery to parasitophorous vacuoles where they kill intracellular microbes. © 2011 Landes Bioscience.

Keyword(s)

Biochemistry, Genetics and Molecular Biology

Availability

URI

https://repository.li.mahidol.ac.th/handle/20.500.14594/11613

Collections

Scopus 2011-2015