Publication: Evidence for a dualistic model of high-grade serous carcinoma: BRCA mutation status, histology, and tubal intraepithelial carcinoma
Issued Date
2015-01-01
Resource Type
ISSN
15320979
01475185
01475185
Other identifier(s)
2-s2.0-84924071135
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Mahidol University
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SCOPUS
Bibliographic Citation
American Journal of Surgical Pathology. Vol.39, No.3 (2015), 287-293
Suggested Citation
Brooke E. Howitt, Suchanan Hanamornroongruang, Douglas I. Lin, James E. Conner, Stephanie Schulte, Neil Horowitz, Christopher P. Crum, Emily E. Meserve Evidence for a dualistic model of high-grade serous carcinoma: BRCA mutation status, histology, and tubal intraepithelial carcinoma. American Journal of Surgical Pathology. Vol.39, No.3 (2015), 287-293. doi:10.1097/PAS.0000000000000369 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/36798
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Title
Evidence for a dualistic model of high-grade serous carcinoma: BRCA mutation status, histology, and tubal intraepithelial carcinoma
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Abstract
Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved. Most early adnexal carcinomas detected in asymptomatic women with germline BRCA mutations (BRCA +) present as serous tubal intraepithelial carcinomas (STIC). However, STICs are found in only ∼40% of symptomatic high-grade serous carcinomas (HGSCs) and less frequently in pseudoendometrioid variants of HGSC. Consecutive cases of untreated HGSC from BRCA + and BRCA - women with detailed fallopian tube examination (SEE-FIM protocol) were compared. STIC status (+/-) was determined, and tumors were classified morphologically as SET ("SET", >50% solid, pseudoendometrioid, or transitional) or classic predominate ("Classic"). SET tumors trended toward a higher frequency in BRCA + versus BRCA - women (50% vs. 28%, P=0.11), had a significantly younger mean age than those with classic HGSC in BRCA - women (mean 56.2 vs. 64.8 y, P=0.04), and displayed a better clinical outcome in both groups combined (P=0.024). STIC was significantly more frequent in tumors from the BRCA - cohort (66% vs. 31%, P=0.017) and specifically the BRCA - tumors with classic morphology (83%) versus those with SET morphology (22%, P=0.003). Overall, several covariables - histology, BRCA status, age, coexisting STIC, and response to therapy - define 2 categories of HGSC with differences in precursor (STIC) frequency, morphology, and outcome. We introduce a dualistic HGSC model that could shed light on the differences in frequency of STIC between symptomatic and asymptomatic women with HGSC. This model emphasizes the need for further study of HGSC precursors to determine their relevance to the prevention of this lethal malignancy.