Publication: Efficacy and safety of parenteral amoxycillin/clavulanate for prevention of surgical site infection following abdominal surgery
Issued Date
2009-09-01
Resource Type
ISSN
01252208
01252208
01252208
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2-s2.0-70349299886
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of the Medical Association of Thailand. Vol.92, No.9 (2009), 1167-1170
Suggested Citation
Darin Lohsiriwat, Vitoon Chinswangwatanakul, Varut Lohsiriwat, Amorn Leelaratsamee Efficacy and safety of parenteral amoxycillin/clavulanate for prevention of surgical site infection following abdominal surgery. Journal of the Medical Association of Thailand. Vol.92, No.9 (2009), 1167-1170. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/27959
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Title
Efficacy and safety of parenteral amoxycillin/clavulanate for prevention of surgical site infection following abdominal surgery
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Abstract
Objective: The aim of the present study was to evaluate the efficacy and safety of parenteral amoxycillin/ clavulanate for the prevention of surgical site infection (SSI) following intra-abdominal surgery. Material and Method: This prospective opened non-comparative clinical trial was conducted in the Department of Surgery, Faculty of Medicine Siriraj Hospital, Bangkok, Thailand between 1 April 2004 and 30 September 2004. Prophylactic amoxycillin/clavulanate (Cavumox®) at a dose of 1.2 gram was given intravenously to all patients who underwent emergency or elective intra-abdominal procedures. All patients were scheduled to follow-up visits at 7, 14 and 30 days post operatively for monitoring the occurrence of SSI. Results: Thirty emergency appendectomies (85.7%) and other 5 elective surgical procedures (14.3%) were performed in 35 patients including 14 males and 21 females with a mean age of 37 (range, 18-72) years. No SSI or drug allergy was observed. Conclusion: Parenteral amoxycillin/clavulanate is a safe and effective antibiotic as the monotherapy for prevention of SSI following intra-abdominal surgery.