Publication: Silencing of PmYPR65 receptor prevents yellow head virus infection in Penaeus monodon
Issued Date
2014-08-30
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ISSN
18727492
01681702
01681702
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2-s2.0-84905985317
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Mahidol University
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SCOPUS
Bibliographic Citation
Virus Research. Vol.189, (2014), 133-135
Suggested Citation
Wanchai Assavalapsakul, Hoa Khanh Tran Kiem, Duncan R. Smith, Sakol Panyim Silencing of PmYPR65 receptor prevents yellow head virus infection in Penaeus monodon. Virus Research. Vol.189, (2014), 133-135. doi:10.1016/j.virusres.2014.05.022 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/33229
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Title
Silencing of PmYPR65 receptor prevents yellow head virus infection in Penaeus monodon
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Abstract
The suppression of viral replication by double-stranded RNAs (dsRNA) specific to mRNAs of either virus or host genes has been widely investigated as a possible shrimp disease therapy. PmYRP65, a yellow head virus (YHV) receptor, was previously identified and characterized in the black tiger shrimp, Penaeus monodon. In our previous study, entry of YHV into cells of the Oka organ of P. monodon required the host receptor PmYRP65 and silencing of PmYRP65 in vitro led to a complete suppression of YHV replication in the cells. In this study, PmYRP65 was shown to be in vivo suppressed by dsRNA specific for PmYRP65, leading to inhibition of YHV replication and almost complete abolition of shrimp mortality following YHV challenge. Targeting PmYRP65 could be an effective YHV antiviral shrimp strategy. © 2014 Elsevier B.V.