Publication: Health-Related Quality of Life in Pediatric Liver Transplant Recipients
Issued Date
2020-01-01
Resource Type
ISSN
18732623
00411345
00411345
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2-s2.0-85085305763
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Mahidol University
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SCOPUS
Bibliographic Citation
Transplantation Proceedings. (2020)
Suggested Citation
Songpon Getsuwan, Pornthep Tanpowpong, Chatmanee Lertudomphonwanit, Jariya Chuthapisith, Napapat Butsriphum, Wasuntara Prabpram, Rarong Charoenmuang, Suporn Treepongkaruna Health-Related Quality of Life in Pediatric Liver Transplant Recipients. Transplantation Proceedings. (2020). doi:10.1016/j.transproceed.2020.02.175 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/56290
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Title
Health-Related Quality of Life in Pediatric Liver Transplant Recipients
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Abstract
© 2020 Elsevier Inc. Background: Health-related quality of life (HRQoL) of liver transplantation (LT) recipients has been widely studied because of increased patient longevity. However, studies in developing countries are scanty. We aimed to evaluate psychometric properties of the Thai version of the PedsQL Transplant Module and used it to determine the HRQoL in LT children. Methods: We included children aged 2 to 18 years who underwent LT more than 1 year previously. The phase 1 study included a cognitive interview with 20 LT children and their parents using the Thai version of PedsQL Transplant Module and revised the module accordingly. Then, the finalized version was evaluated for psychometric properties in 50 LT children. In phase 2, HRQoL was evaluated in 52 LT children who did not participate in the phase 1 study. Results: In the Thai PedsQL Transplant Module, both parent report and child self-report had good internal consistency (α = 0.94 and 0.93, respectively) and substantial reliability (interclass correlation coefficient = 0.82 and 0.77, respectively). Median HRQoL scores from the parent report and child self-report were 80 (interquartile range [IQR], 70, 88) and 77 (IQR, 71, 88), respectively. From the parent report, lower HRQoL was associated with opportunistic viral infection (P = .004) and correlated with a greater number of immunosuppressive agents (ρ = –0.346, P = .014). However, none of these factors were significant according to the child self-report. Conclusions: The Thai PedsQL Transplant Module has satisfactory psychometric properties. Post-LT children have good HRQoL. To improve their HRQoL, specific attention should be focused on managing viral infection and optimizing immunosuppressive therapy.