Publication: Cytotoxic tropolones from the fungus Nemania sp. BCC 30850
Issued Date
2017-01-01
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ISSN
14645416
00404020
00404020
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2-s2.0-85019462618
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Mahidol University
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SCOPUS
Bibliographic Citation
Tetrahedron. Vol.73, No.25 (2017), 3505-3512
Suggested Citation
Jittra Kornsakulkarn, Siriporn Saepua, Rapheephat Suvannakad, Sumalee Supothina, Nattawut Boonyuen, Masahiko Isaka, Samran Prabpai, Palangpon Kongsaeree, Chawanee Thongpanchang Cytotoxic tropolones from the fungus Nemania sp. BCC 30850. Tetrahedron. Vol.73, No.25 (2017), 3505-3512. doi:10.1016/j.tet.2017.05.030 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/41991
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Title
Cytotoxic tropolones from the fungus Nemania sp. BCC 30850
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Abstract
© 2017 Elsevier Ltd Twelve new compounds, including nine tropolones, nemanolones A−I (1–9), three 7-isochromenones, nemanecins A−C (10–12), and a new naturally isolated 4-isochromanone (13), along with two known compounds, 7,8-dihydroxy-3-methyl isochroman-4-one (XJP), and chaetoquadrin F, were isolated from culture broth of the fungus Nemania sp. BCC 30850. Structures of these compounds were elucidated by NMR and MS spectroscopic analyses. Nemanolones exhibited cytotoxic activities and two of them, compounds 1 and 2, also showed antibacterial activity against Bacillus cereus and antifungal activity against Candida albicans.