Publication: Clinical and hematologic aspects of hemoglobin E β-thalassemia
Issued Date
2000-03-02
Resource Type
ISSN
10656251
Other identifier(s)
2-s2.0-0033953189
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Current Opinion in Hematology. Vol.7, No.2 (2000), 106-112
Suggested Citation
Suthat Fucharoen, Pranee Winichagoon Clinical and hematologic aspects of hemoglobin E β-thalassemia. Current Opinion in Hematology. Vol.7, No.2 (2000), 106-112. doi:10.1097/00062752-200003000-00006 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/26264
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Clinical and hematologic aspects of hemoglobin E β-thalassemia
Author(s)
Other Contributor(s)
Abstract
Hemoglobin E β-thalassemia is an important cause of childhood chronic disease in Southeast Asia. It is characterized by the presence of hemoglobin E and F, and the amount of hemoglobin E ranges from 35% to 75%. The patients are generally classified as having thalassemia intermedia because they have inherited a β-thalassemia allele and hemoglobin E, which acts as a mild β+-thalassemia. However, a remarkable variability in the clinical expression, ranging from a mild form of thalassemia intermedia to transfusion-dependent conditions, is observed. Severe hemoglobin E β- thalassemia may have clinical features of thalassemia major. Phenotypes of thalassemia major can be predicted from the early onset of clinical symptoms and the requirement of regular blood transfusion from infancy for survival. Coinheritance of α-thalassemia alleviated the severity of β-thalassemia disease in patients with at least one allele of mild β-thalassemia genotype. (C) 2000 Lippincott Williams and Wilkins, Inc.