Publication: Binding antibody to neutralizing epitope gp41 in HIV-1 subtype CRF 01_AE infection related to stage of disease
Issued Date
2005-01-01
Resource Type
ISSN
01251562
Other identifier(s)
2-s2.0-17744370178
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Mahidol University
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SCOPUS
Bibliographic Citation
Southeast Asian Journal of Tropical Medicine and Public Health. Vol.36, No.1 (2005), 221-227
Suggested Citation
Surangrat Srisurapanon, Suda Louisirirotchanakul, Kwonchit Sumransurp, Monthaswad Ratanasrithong, Thippawan Chuenchitra, Siriporn Jintakatkorn, Chantapong Wasi Binding antibody to neutralizing epitope gp41 in HIV-1 subtype CRF 01_AE infection related to stage of disease. Southeast Asian Journal of Tropical Medicine and Public Health. Vol.36, No.1 (2005), 221-227. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/17137
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Title
Binding antibody to neutralizing epitope gp41 in HIV-1 subtype CRF 01_AE infection related to stage of disease
Abstract
The responsiveness of gp41 antibody against epitope ELDKWA in HIV-1 infected subjects is of importance in neutralizing viral infectivity and for being related to disease progression. In this study, antibody titers to this neutralizing epitope from HIV-1 infected subjects at asymptomatic and AIDS stages in Thailand were investigated by peptide ELISA. The results showed that the frequency of antibody production against this neutralizing epitope was low (15-35%). Moreover, antibody titers to this epitope in sera from AIDS patients were significantly lower than those in sera from asymptomatic subjects which were collected in the same year (p=0.001). Comparison between the past (1992-1994) and present (2002) sera from asymptomatic infected individuals revealed that the earlier panel contained lower antibody titers than the later panel did (p=0.05). In addition, random sera for HIV-1 infected subjects who were infected by diverse genetic subtypes, (A through G) including CRF 01_AE, had low titers of antibody to this region as well. It is assumed that antibody production to this epitope is low and related to the stage of HIV-1 infection.