Publication: Pharmacokinetics of zidovudine phosphorylation in human immunodeficiency virus-positive Thai patients and healthy volunteers
Issued Date
2000-07-01
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ISSN
00664804
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2-s2.0-0033933615
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Mahidol University
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SCOPUS
Bibliographic Citation
Antimicrobial Agents and Chemotherapy. Vol.44, No.7 (2000), 1986-1989
Suggested Citation
Yupaporn Wattanagoon, Kesara Na Bangchang, Patrick G. Hoggard, Saye H. Khoo, Sara E. Gibbons, Danabhand Phiboonbhanakit, Juntra Karbwang, David J. Back Pharmacokinetics of zidovudine phosphorylation in human immunodeficiency virus-positive Thai patients and healthy volunteers. Antimicrobial Agents and Chemotherapy. Vol.44, No.7 (2000), 1986-1989. doi:10.1128/AAC.44.7.1986-1989.2000 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/26212
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Title
Pharmacokinetics of zidovudine phosphorylation in human immunodeficiency virus-positive Thai patients and healthy volunteers
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Abstract
We assessed the pharmacokinetics of zidovudine (ZDV) in plasma and intracellular ZDV phosphate anabolites in peripheral blood mononuclear cells in Thai human immunodeficiency virus (HIV) type 1-infected patients and healthy volunteers. The plasma ZDV area under the concentration-time curve from 0 to 6 h (AUC0-6) was similar in patients and healthy volunteers (32.77 and 22.77 μmol/liter · h, respectively; confidence interval, -3.37 to 19.92). Although the concentration of ZDV triphosphate (ZDVTP) was similar in the two groups, the ZDV monophosphate (ZDVMP) AUC0-6 was significantly greater in HIV patients (1.12 pmol/106 cells) than in healthy volunteers (0.15 pmol/106 cells). In agreement with previously published data obtained with Caucasians, the significant difference in intracellular phosphorylation in Thai volunteers and HIV patients is primarily due to ZDVMP. Comparing the data from this study with the data obtained with Caucasians suggests no marked ethnic differences in ZDV phosphorylation.