Publication: Mycobacterial skin infections: Comparison between histopathologic features and detection of acid fast bacilli in pathologic section
Issued Date
2004-06-01
Resource Type
ISSN
01252208
Other identifier(s)
2-s2.0-3543141729
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Journal of the Medical Association of Thailand. Vol.87, No.6 (2004), 709-712
Suggested Citation
Punkae Mahaisavariya, Jane Manonukul, Supakan Khemngern, Angkana Chaiprasert Mycobacterial skin infections: Comparison between histopathologic features and detection of acid fast bacilli in pathologic section. Journal of the Medical Association of Thailand. Vol.87, No.6 (2004), 709-712. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/21642
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Mycobacterial skin infections: Comparison between histopathologic features and detection of acid fast bacilli in pathologic section
Other Contributor(s)
Abstract
Background: Detection of acid fast bacilli (AFB) in chronic granulomatous inflammation is an important clue for mycobacterial infection. Design: A retrospective review of 104 pathologic sections (from 1994 to 2001) of suspected cases of mycobacterial (tuberculous and nontuberculous) skin infections to study histopathologic features and the correlation with the presence of AFB in the section was performed. Results: All cases showed granulomatous inflammations that can be categorized into 4 types: mixed cell, suppurative, tuberculoid and palisading granuloma. AFB was found in 32 sections (30.77%). Ninety five specimens from 104 specimens were simultaneously cultured. AFB positive cases yielded higher positive cultural results, 17 from 29 cases (58.62%) compared to the AFB negative group, 23 from 66 cases, (34.85%). Mixed cell granuloma was the most common histologic feature, but suppurative granuloma was the most common histological feature (56.25%) in which AFB could be found, which was statistically significantly different from other types of granuloma. Tuberculoid granuloma was more common in the AFB negative group (20.83%) compared to the AFB positive group (9.37%) but the difference was not statistically significant. In cases that AFB could not be found, the inflammation tended to be located in the upper half of the dermis. Conclusion: AFB can be more frequently detected in suppurative granuloma that might be located in any portion of the dermis. This finding was not species specific.