Publication: Role of Calcium sensing receptor (CaSR) in tumorigenesis
5
Issued Date
2013-01-01
Resource Type
ISSN
15321908
1521690X
1521690X
Other identifier(s)
2-s2.0-85027945625
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Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Best Practice and Research: Clinical Endocrinology and Metabolism. Vol.27, No.3 (2013), 455-463
Suggested Citation
Navneet Singh, Moltira Promkan, Guangming Liu, James Varani, Subhas Chakrabarty Role of Calcium sensing receptor (CaSR) in tumorigenesis. Best Practice and Research: Clinical Endocrinology and Metabolism. Vol.27, No.3 (2013), 455-463. doi:10.1016/j.beem.2013.04.001 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/31417
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Title
Role of Calcium sensing receptor (CaSR) in tumorigenesis
Abstract
The extracellular Ca2+-sensing receptor (CaSR) is a robust promoter of differentiation in colonic epithelial cells and functions as a tumor suppressor in colon cancer. CaSR mediates its biologic effects through diverse mechanisms. Loss of CaSR expression activates a myriad of stem cell-like molecular features that drive and sustain the malignant and drug-resistant phenotypes of colon cancer. This CaSR-null phenotype, however, is not irreversible and induction of CaSR expression in CaSR-null cells promotes cell death mechanisms and restores drug sensitivity. The CaSR also functions as a tumor suppressor in breast cancer and promotes cellular sensitivity to cytotoxic drugs. BRCA1 and CaSR functions intersect in breast cancer cells, and CaSR activation can rescue breast cancer cells from the deleterious effect of BRCA1 mutations. © 2013 Elsevier Ltd. All rights reserved.