Publication: Identification of ancestry informative markers from chromosome-wide single nucleotide polymorphisms using symmetrical uncertainty ranking
Issued Date
2010-11-18
Resource Type
ISSN
10514651
Other identifier(s)
2-s2.0-78149487330
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Proceedings - International Conference on Pattern Recognition. (2010), 2448-2451
Suggested Citation
Theera Piroonratana, Waranyu Wongseree, Touchpong Usavanarong, Anunchai Assawamakin, Chanin Limwongse, Nachol Chaiyaratana Identification of ancestry informative markers from chromosome-wide single nucleotide polymorphisms using symmetrical uncertainty ranking. Proceedings - International Conference on Pattern Recognition. (2010), 2448-2451. doi:10.1109/ICPR.2010.599 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/28997
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Identification of ancestry informative markers from chromosome-wide single nucleotide polymorphisms using symmetrical uncertainty ranking
Other Contributor(s)
Abstract
Ancestry informative markers (AIMs) have been proven to contain necessary information for population classification. In this article, round robin symmetrical uncertainty ranking for preliminary AIM screening is proposed. Each single nucleotide polymorphism (SNP) is assigned a rank based on its ability to separate two populations from each other. In a multi-population scenario, all possible population pairs are considered and the screened SNP set incorporates top-ranked SNPs from every pair-wise comparison. After the preliminary screening, SNPs are further screened by a wrapper which is embedded with a naive Bayes classifier. A classification model is subsequently constructed from the finally screened SNPs via a naive Bayes classifier. The application of the proposed procedure to the HapMap data indicates that AIM panels can be found on all chromosomes. Each panel consists of 11 to 24 SNPs and can be used to completely classify the CEU, CHB, JPT and YRI populations. Moreover, all panels are smaller than the AIM panels reported in previous studies. © 2010 IEEE.