Publication: Digested moringa oleifera boiled pod exhibits anti-inflammatory activity in caco-2 cells
Issued Date
2015-04-03
Resource Type
ISSN
15403580
10496475
10496475
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2-s2.0-84906539774
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of Herbs, Spices and Medicinal Plants. Vol.21, No.2 (2015), 148-160
Suggested Citation
Kamika Praengam, Chanwanphat Muangnoi, Suwitcha Dawilai, Momwirin Awachanawong, Siriporn Tuntipopipat Digested moringa oleifera boiled pod exhibits anti-inflammatory activity in caco-2 cells. Journal of Herbs, Spices and Medicinal Plants. Vol.21, No.2 (2015), 148-160. doi:10.1080/10496475.2014.932880 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/36471
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Title
Digested moringa oleifera boiled pod exhibits anti-inflammatory activity in caco-2 cells
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Abstract
Pretreatment of Caco-2 cells with the bioaccessible fraction of bMO suppressed IL-1β-induced COX-2, IL-8 and MCP-1 and intracellular ROS content. Omission of bile extract during digestion decreased the extent of inhibitory effect of digested bMO on IL-1β activated IL-8 and MCP-1 production. Both lipophilic and hydrophilic compounds of bMO contribute to suppressive response to the pro-inflammatory insult, but only the hydrophilic compounds are responsible for its antioxidant activity. The suppressive effect of the bioaccessible fraction of bMO was partly modulated by inhibiting the phosphorylation of p-38 and IκB. These data provide supportive health promoting activity of M. oleifera pods on the gut. © Taylor & Francis Group, LLC.