Publication:
Genome-wide association study identifies susceptibility loci for dengue shock syndrome at MICB and PLCE1

Issued Date

2011-11-01

Resource Type

Article

ISSN

15461718
10614036

DOI

10.1038/ng.960

Other identifier(s)

2-s2.0-80055010567

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

Nature Genetics. Vol.43, No.11 (2011), 1139-1141

Suggested Citation

Chiea Chuen Khor, Tran Nguyen Bich Chau, Junxiong Pang, Sonia Davila, Hoang Truong Long, Rick T.H. Ong, Sarah J. Dunstan, Bridget Wills, Jeremy Farrar, Ta Van Tram, Tran Thi Gan, Nguyen Thi Nguyet Binh, Le Trung Tri, Le Bich Lien, Nguyen Minh Tuan, Nguyen Thi Hong Tham, Mai Ngoc Lanh, Nguyen Minh Nguyet, Nguyen Trong Hieu, Nguyen Van N Vinh Chau, Tran Thi Thuy, Dennis E.K. Tan, Anavaj Sakuntabhai, Yik Ying Teo, Martin L. Hibberd, Cameron P. Simmons Genome-wide association study identifies susceptibility loci for dengue shock syndrome at MICB and PLCE1. Nature Genetics. Vol.43, No.11 (2011), 1139-1141. doi:10.1038/ng.960 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/11449

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Title

Genome-wide association study identifies susceptibility loci for dengue shock syndrome at MICB and PLCE1

Author(s)

Chiea Chuen Khor
 Tran Nguyen Bich Chau
 Junxiong Pang
 Sonia Davila
 Hoang Truong Long
 Rick T.H. Ong
 Sarah J. Dunstan
 Bridget Wills
 Jeremy Farrar
 Ta Van Tram
 Tran Thi Gan
 Nguyen Thi Nguyet Binh
 Le Trung Tri
 Le Bich Lien
 Nguyen Minh Tuan
 Nguyen Thi Hong Tham
 Mai Ngoc Lanh
 Nguyen Minh Nguyet
 Nguyen Trong Hieu
 Nguyen Van N Vinh Chau
 Tran Thi Thuy
 Dennis E.K. Tan
 Anavaj Sakuntabhai
 Yik Ying Teo
 Martin L. Hibberd
 Cameron P. Simmons

Other Contributor(s)

Genome Institute of Singapore
 National University of Singapore
 Yong Loo Lin School of Medicine
 Oxford University Clinical Research Unit
 Nuffield Department of Clinical Medicine
 Tien Giang Hospital
 Sa Dec Hospital
 Children's Hospital No. 1
 Dong Thap Hospital
 Hung Vuong Hospital
 UCL
 Children's Hospital No. 2
 Institut Pasteur, Paris
 Mahidol University

Abstract

Hypovolemic shock (dengue shock syndrome (DSS)) is the most common life-threatening complication of dengue. We conducted a genome-wide association study of 2,008 pediatric cases treated for DSS and 2,018 controls from Vietnam. Replication of the most significantly associated markers was carried out in an independent Vietnamese sample of 1,737 cases and 2,934 controls. SNPs at two loci showed genome-wide significant association with DSS. We identified a susceptibility locus at MICB (major histocompatibility complex (MHC) class I polypeptide-related sequence B), which was within the broad MHC region on chromosome 6 but outside the class I and class II HLA loci (rs3132468, P meta = 4.41 × 10 -11 , per-allele odds ratio (OR) = 1.34 (95% confidence interval: 1.23-1.46)). We identified associated variants within PLCE1 (phospholipase C, epsilon 1) on chromosome 10 (rs3765524, P meta = 3.08 × 10 -10 , per-allele OR = 0.80 (95% confidence interval: 0.75-0.86)). We identify two loci associated with susceptibility to DSS in people with dengue, suggesting possible mechanisms for this severe complication of dengue. © 2011 Nature America, Inc. All rights reserved.

Keyword(s)

Biochemistry, Genetics and Molecular Biology

Availability

URI

https://repository.li.mahidol.ac.th/handle/20.500.14594/11449

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Scopus 2011-2015