Publication: Antioxidant activity of Siamese neem tree (VP1209)
Issued Date
2005-05-13
Resource Type
ISSN
03788741
Other identifier(s)
2-s2.0-17644421819
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Journal of Ethnopharmacology. Vol.99, No.1 (2005), 109-112
Suggested Citation
Pongtip Sithisarn, Roongtawan Supabphol, Wandee Gritsanapan Antioxidant activity of Siamese neem tree (VP1209). Journal of Ethnopharmacology. Vol.99, No.1 (2005), 109-112. doi:10.1016/j.jep.2005.02.008 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/17164
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Antioxidant activity of Siamese neem tree (VP1209)
Other Contributor(s)
Abstract
Leaves, fruits, flowers and stem bark extracts from the Siamese neem tree (Azadirachta indica A. Juss var. siamensis Valeton, Meliaceae) were assessed for antioxidant activity in vitro using the 1,1-diphenyl-2-picryl hydrazyl (DPPH) scavenging assay, total antioxidant activity and inhibition of lipid peroxidation in Chago K1 cancer cell culture by the thiobarbituric acid reactive substances (TBARS) method. The results showed that leaf aqueous extract, flower and stem bark ethanol extracts exhibited higher free radical scavenging effect on the DPPH assay with 50% scavenging activity at 26.5, 27.9 and 30.6 μg/ml, respectively. The total antioxidant activity of these extracts was found to be 0.959, 0.988 and 1.064 mM of standard trolox, respectively. At 100 μg/ml, the flower ethanol and leaf aqueous extracts significantly decreased malondialdehyde (MDA) levels (46.0 and 50.6%, respectively) by the TBARS method. The results suggest that extracts from leaf, flower and stem bark of the Siamese neem tree have strong antioxidant potential. This report supports the ethnomedical use of young leaves and flowers of this plant as a vegetable bitter tonic to promote good health. © 2005 Elsevier Ireland Ltd. All rights reserved.