Publication: Thiamin deficiency and uncomplicated falciparum malaria in Laos
Issued Date
2007-03-01
Resource Type
ISSN
13653156
13602276
13602276
Other identifier(s)
2-s2.0-33847100548
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Tropical Medicine and International Health. Vol.12, No.3 (2007), 363-369
Suggested Citation
Mayfong Mayxay, Ann M. Taylor, Maniphone Khanthavong, Siamphay Keola, Tiengkham Pongvongsa, Samlane Phompida, Rattanaxay Phetsouvanh, Nicholas J. White, Paul N. Newton Thiamin deficiency and uncomplicated falciparum malaria in Laos. Tropical Medicine and International Health. Vol.12, No.3 (2007), 363-369. doi:10.1111/j.1365-3156.2006.01804.x Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/24577
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Title
Thiamin deficiency and uncomplicated falciparum malaria in Laos
Abstract
Objective: Thiamin deficiency complicates severe Plasmodium falciparum malaria in Thailand and may contribute to acidosis. We therefore estimated the frequency of biochemical thiamin deficiency in patients presenting with uncomplicated falciparum malaria in southern Laos. Methods: Red cell transketolase activation coefficients (α) were measured in 310 patients presenting with uncomplicated falciparum malaria and 42 days after starting treatment. Results: Twelve per cent of patients had biochemical evidence of severe deficiency (α values >1.31) at presentation, declining to 3% 42 days later. Conclusion: Thiamin deficiency was common in Lao patients admitted with uncomplicated P. falciparum infection and was reduced following treatment of malaria and multivitamin supplementation. The role of this preventable and treatable disorder in malaria and other acute infections, and the incidence of beriberi in rural Laos, needs further investigation. © 2007 Blackwell Publishing Ltd.