Lipid composition of serum lipoprotein in opisthorchiasis

Abstract

Lipid composition (i.e. total cholesterol, free cholesterol, cholesteryl ester, triglycerides and phospholipids) in the individual serum lipoprotein fraction (i.e. high-density lipoprotein, low-density lipoprotein and very low-density lipoprotein) were studied in 24 healthy controls and 18 opisthorchiasis patients admitted to the Bangkok Hospital for Tropical Diseases, Faculty of Tropical Medicine. The two groups were similar in age range, sex ratio and anthropometric data. Other background data such as blood pressure and alcohol consumption, were also similar in the two groups. All the patients had the habit of eating raw or half-cooked fish. Abnormalities of high-density lipoprotein content in the opisthorchiasis group showed as low cholesterol and cholesteryl ester concentrations but with high triglyceride concentrations. These may result from disturbance of the synthesis of nascent disk high-density lipoprotein or the removal of lipid content in lipoproteins.