Publication: Retinal changes in visceral leishmaniasis by retinal photography
Issued Date
2014
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Language
eng
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Mahidol University
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BioMed Central
Bibliographic Citation
BMC Public Health. Vol.14, (2014), 527
Suggested Citation
Maude, Richard James, Ahmed, BUM Wahid, Abu Hayat Md Waliur Rahman, Rahman, Ridwanur, Majumder, Mohammed Ishaque, Menezes, Darryl Braganza, Sayeed, Abdullah Abu, Hughes, Laura, MacGillivray, Thomas J, Borooah, Shyamanga, Dhillon, Baljean, Dondorp, Arjen M, Faiz, Mohammad Abul Retinal changes in visceral leishmaniasis by retinal photography. BMC Public Health. Vol.14, (2014), 527. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/2841
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Title
Retinal changes in visceral leishmaniasis by retinal photography
Abstract
Background: In visceral leishmaniasis (VL), retinal changes have previously been noted but not described in detail
and their clinical and pathological significance are unknown. A prospective observational study was undertaken in
Mymensingh, Bangladesh aiming to describe in detail visible changes in the retina in unselected patients with VL.
Methods: Patients underwent assessment of visual function, indirect and direct ophthalmoscopy and portable
retinal photography. The photographs were assessed by masked observers including assessment for vessel
tortuosity using a semi-automated system.
Results: 30 patients with VL were enrolled, of whom 6 (20%) had abnormalities. These included 5 with focal retinal
whitening, 2 with cotton wool spots, 2 with haemorrhages, as well as increased vessel tortuosity. Visual function
was preserved.
Conclusions: These changes suggest a previously unrecognized retinal vasculopathy. An inflammatory aetiology is
plausible such as a subclinical retinal vasculitis, possibly with altered local microvascular autoregulation, and
warrants further investigation.