Publication: Cognitive impairment associated with increased mortality rate in patients with heart failure: A systematic review and meta-analysis
Issued Date
2019-10-01
Resource Type
ISSN
22125043
10167315
10167315
Other identifier(s)
2-s2.0-85068355745
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of the Saudi Heart Association. Vol.31, No.4 (2019), 170-178
Suggested Citation
Jakrin Kewcharoen, N. Prasitlumkum, Chanavuth Kanitsoraphan, Nattawat Charoenpoonsiri, Natthapon Angsubhakorn, Prapaipan Putthapiban, Pattara Rattanawong Cognitive impairment associated with increased mortality rate in patients with heart failure: A systematic review and meta-analysis. Journal of the Saudi Heart Association. Vol.31, No.4 (2019), 170-178. doi:10.1016/j.jsha.2019.06.001 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/51395
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Title
Cognitive impairment associated with increased mortality rate in patients with heart failure: A systematic review and meta-analysis
Abstract
© 2019 The Authors Background: Recent systematic review and meta-analysis showed that the prevalence of cognitive impairment was significantly increased in patients with heart failure (HF) when compared to the general population. However, the effect of cognitive impairment on cardiovascular outcome in this population is still unclear. We performed a systematic review and meta-analysis to assess whether cognitive impairment associated with worse outcome in patients with HF. Methods: We comprehensively searched the databases of MEDLINE and EMBASE from inception to October 2018. Included studies were published cohort (prospective or retrospective) or randomized control trials that evaluate the effect of cognitive impairment mortality in HF patients. Data from each study were combined using the random-effects, generic inverse variance method of DerSimonian and Laird to calculate pooled hazard ratios (HR) and 95% confidence intervals (CI). Results: Eight studies were included in the analysis involving 3318 participants (951 participants had cognitive impairment). In a random-effects model, our analysis demonstrated that cognitive impairment significantly increased the risk of mortality in HF patients (pooled HR = 1.64, 95% CI = 1.42–1.88, I2 = 0.0%, p < 0.001). Conclusion: Our systematic review and meta-analysis showed that the presence of cognitive impairment is strongly associated with an increased mortality risk in the HF population. Further research is needed to explore the pathophysiology of this association.