Publication: The usefulness of homeostatic measurement assessment-insulin resistance (HOMA-IR) for detection of glucose intolerance in Thai women of reproductive age with polycystic ovary syndrome
2
Issued Date
2012-07-16
Resource Type
ISSN
16878345
16878337
16878337
Other identifier(s)
2-s2.0-84863649918
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
International Journal of Endocrinology. Vol.2012, (2012)
Suggested Citation
Thanyarat Wongwananuruk, Manee Rattanachaiyanont, Pichai Leerasiri, Suchada Indhavivadhana, Kitirat Techatraisak, Surasak Angsuwathana, Prasong Tanmahasamut, Chongdee Dangrat The usefulness of homeostatic measurement assessment-insulin resistance (HOMA-IR) for detection of glucose intolerance in Thai women of reproductive age with polycystic ovary syndrome. International Journal of Endocrinology. Vol.2012, (2012). doi:10.1155/2012/571035 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/13662
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
The usefulness of homeostatic measurement assessment-insulin resistance (HOMA-IR) for detection of glucose intolerance in Thai women of reproductive age with polycystic ovary syndrome
Other Contributor(s)
Abstract
Objectives. To study the cut-off point of Homeostatic Measurement Assessment-Insulin Resistance (HOMA-IR) as a screening test for detection of glucose intolerance in Thai women with polycystic ovary syndrome (PCOS). Study Design. Cross-sectional study. Setting. Department of Obstetrics and Gynecology, Faculty of Medicine Siriraj Hospital. Subject. Two hundred and fifty Thai PCOS women who attended the Gynecologic Endocrinology Unit, during May 2007 to January 2009. Materials and Methods. The paitents were interviewed and examined for weight, height, waist circumference, and blood pressure. Venous blood samples were drawn twice, one at 12-hour fasting and the other at 2 hours after glucose loading. Results. The prevalence of glucose intolerance in Thai PCOS women was 20.0. The mean of HOMA-IR was 3.53 ± 7.7. Area under an ROC curve for HOMA-IR for detecting glucose intolerance was 0.82. Using the cut-off value of HOMA-IR 2.0, there was sensitivity at 84.0, specificity at 61.0, positive predictive value at 35.0, negative predictive value at 93.8, and accuracy at 65.6. Conclusion. HOMA-IR 2.0 was used for screening test for glucose intolerance in Thai PCOS women. If the result was positive, a specific test should be done to prove the diagnosis. Copyright © 2012 Thanyarat Wongwananuruk et al.