Publication: Antibody responses in human gnathostomiasis.
Issued Date
1988-06-01
Resource Type
ISSN
01251562
Other identifier(s)
2-s2.0-0024033040
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Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
The Southeast Asian journal of tropical medicine and public health. Vol.19, No.2 (1988), 219-224
Suggested Citation
C. Nopparatana, P. Tapchaisri, P. Setasubun, W. Chaicumpa, P. Dekumyoy Antibody responses in human gnathostomiasis.. The Southeast Asian journal of tropical medicine and public health. Vol.19, No.2 (1988), 219-224. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/15614
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Title
Antibody responses in human gnathostomiasis.
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Abstract
Sera from 4 patients with parasitologically confirmed gnathostomiasis and from 18 healthy individuals were studied by SDS-PAGE and Western blot analysis using radioiodinated protein A to detect antibody responses against crude aqueous somatic extract of advanced third stage larvae of Gnathostoma spinigerum (L3G). It was found that the L3G extract was highly complex, comprising of more than 40 polypeptides among which more than 20 components were antigenic in human. The relative M.W. of the proteins ranged from 13 kd to 150 kd with the major antigenic bands at 150, 135, 120, 94, 84, 82, 72, 55, 54, 49, 43, 38, 35, 32 and 28 kd. All 4 sera from gnathostomiasis patients gave almost an identical pattern of reactivities against the L3G antigens whereas sera from the normal individuals gave much lower reactivities against the L3G antigen of M.W. 38 kd and, in certain individuals, those of 49 and 43 kd. The present findings suggest that the serum antibody response against the parasite is specific and may be useful in a specific or a confirmed immunodiagnosis of human gnathostomiasis.