Publication: Infectious virion capture by HIV-1 gp120-specific IgG from RV144 vaccinees
Issued Date
2013-07-01
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ISSN
10985514
0022538X
0022538X
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2-s2.0-84880310997
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of Virology. Vol.87, No.14 (2013), 7828-7836
Suggested Citation
Pinghuang Liu, Nicole L. Yates, Xiaoying Shen, Mattia Bonsignori, M. Anthony Moody, Hua Xin Liao, Youyi Fong, S. Munir Alam, R. Glenn Overman, Thomas Denny, Guido Ferrari, Christina Ochsenbauer, John C. Kappes, Victoria R. Polonis, Punnee Pitisuttithum, Jaranit Kaewkungwal, Sorachai Nitayaphan, Supachai Rerks-Ngarm, David C. Montefiori, Peter Gilbert, Nelson L. Michael, Jerome H. Kim, Barton F. Haynes, Georgia D. Tomaras Infectious virion capture by HIV-1 gp120-specific IgG from RV144 vaccinees. Journal of Virology. Vol.87, No.14 (2013), 7828-7836. doi:10.1128/JVI.02737-12 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/31901
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Title
Infectious virion capture by HIV-1 gp120-specific IgG from RV144 vaccinees
Author(s)
Pinghuang Liu
Nicole L. Yates
Xiaoying Shen
Mattia Bonsignori
M. Anthony Moody
Hua Xin Liao
Youyi Fong
S. Munir Alam
R. Glenn Overman
Thomas Denny
Guido Ferrari
Christina Ochsenbauer
John C. Kappes
Victoria R. Polonis
Punnee Pitisuttithum
Jaranit Kaewkungwal
Sorachai Nitayaphan
Supachai Rerks-Ngarm
David C. Montefiori
Peter Gilbert
Nelson L. Michael
Jerome H. Kim
Barton F. Haynes
Georgia D. Tomaras
Nicole L. Yates
Xiaoying Shen
Mattia Bonsignori
M. Anthony Moody
Hua Xin Liao
Youyi Fong
S. Munir Alam
R. Glenn Overman
Thomas Denny
Guido Ferrari
Christina Ochsenbauer
John C. Kappes
Victoria R. Polonis
Punnee Pitisuttithum
Jaranit Kaewkungwal
Sorachai Nitayaphan
Supachai Rerks-Ngarm
David C. Montefiori
Peter Gilbert
Nelson L. Michael
Jerome H. Kim
Barton F. Haynes
Georgia D. Tomaras
Abstract
The detailed examination of the antibody repertoire from RV144 provides a unique template for understanding potentially protective antibody functions. Some potential immune correlates of protection were untested in the correlates analyses due to inherent assay limitations, as well as the need to keep the correlates analysis focused on a limited number of endpoints to achieve statistical power. In an RV144 pilot study, we determined that RV144 vaccination elicited antibodies that could bind infectious virions (including the vaccine strains HIV-1 CM244 and HIV-1MNand an HIV-1 strain expressing transmitted/founder Env, B.WITO.c). Among vaccinees with the highest IgG binding antibody profile, the majority (78%) captured the infectious vaccine strain virus (CM244), while a smaller proportion of vaccinees (26%) captured HIV-1 transmitted/founder Env virus. We demonstrated that vaccine-elicited HIV-1 gp120 antibodies of multiple specificities (V3, V2, conformational C1, and gp120 conformational) mediated capture of infectious virions. Although capture of infectious HIV-1 correlated with other humoral immune responses, the extent of variation between these humoral responses and virion capture indicates that virion capture antibodies occupy unique immunological space. ©2013, American Society for Microbiology. All Rights Reserved.