Publication: Including MRI of a primary bone leiomyosarcoma that radiologically mimics a giant cell tumor
Issued Date
2008-02-01
Resource Type
ISSN
01252208
01252208
01252208
Other identifier(s)
2-s2.0-40949100861
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of the Medical Association of Thailand. Vol.91, No.2 (2008), 244-248
Suggested Citation
Vorachai Sirikulchayanonta, Suphaneewan Jaovisidh Including MRI of a primary bone leiomyosarcoma that radiologically mimics a giant cell tumor. Journal of the Medical Association of Thailand. Vol.91, No.2 (2008), 244-248. Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/19766
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Title
Including MRI of a primary bone leiomyosarcoma that radiologically mimics a giant cell tumor
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Abstract
The authors present a case of a 42-year-old female who developed a leiomyosarcoma of the right proximal tibia that appeared radiologically similar to a giant cell tumor. Histology revealed spindle cells running in whorl-like fashion with focal atypia and low mitotic figures. The immuno-stains revealed positive reactivity for alpha-smooth muscle (SMA), muscle actin and cytokeratin (AE1/AE3). The authors rendered a diagnosis of low-grade leiomyosarcoma of bone. The lesion was considered a primary lesion since the patient did not have other leiomyomatous tumors. The MRI showed hypo- to iso- signal intensity on T1-weighted imaging and heterogeneous intensity on T2-weighted imaging. This was likely due to admixed fibrotic tissue in the lesion. The tumor cells were not positive for Ebstein-Barr virus by in-situ hybridization as seen in leiomyomatous tumors in immunodeficiency patients.