Publication: Unveiling Stem Cell Heterogeneity Toward the Development of Salivary Gland Regenerative Strategies
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Issued Date
2019-01-01
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ISSN
22148019
00652598
00652598
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2-s2.0-85065318782
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Mahidol University
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SCOPUS
Bibliographic Citation
Advances in Experimental Medicine and Biology. Vol.1123, (2019), 151-164
Suggested Citation
Ganokon Urkasemsin, Joao N. Ferreira Unveiling Stem Cell Heterogeneity Toward the Development of Salivary Gland Regenerative Strategies. Advances in Experimental Medicine and Biology. Vol.1123, (2019), 151-164. doi:10.1007/978-3-030-11096-3_9 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/50347
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Title
Unveiling Stem Cell Heterogeneity Toward the Development of Salivary Gland Regenerative Strategies
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Abstract
© Springer Nature Switzerland AG 2019. Epithelial damage in the salivary gland (SG) resulting in irreversible dry mouth can be commonly induced by gamma radiation therapy. This radiation depletes the SG stem/progenitor cell niche slowing healing and natural gland regeneration. Biologists have been focused in understanding the development and differentiation of epithelial stem and progenitor cell niches during SG organogenesis. These organogenesis studies gave insights into novel cell-based therapies to recreate the three-dimensional (3D) salivary gland (SG) organ, recapitulate the SG native physiology, and restore saliva secretion. Such therapeutical strategies apply techniques that assemble, in a 3D organotypic culture, progenitor and stem cell lines to develop SG organ-like organoids or mini-transplants. Future studies will employ a combination of organoids, decellularized matrices, and smart biomaterials to create viable and functional SG transplants to repair the site of SG injury and reestablish saliva production.