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Oxidative Difluoromethylation of Tetrahydroisoquinolines Using TMSCF<inf>2</inf>SPh: Synthesis of Fluorinated Pyrrolo[2,1-a]isoquinolines and Benzo[a]quinolizidines

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dc.contributor.authorTeerachai Punirunen_US
dc.contributor.authorDarunee Soorukramen_US
dc.contributor.authorChutima Kuhakarnen_US
dc.contributor.authorVichai Reutrakulen_US
dc.contributor.authorManat Pohmakotren_US
dc.contributor.otherMahidol Universityen_US
dc.date.accessioned2019-08-23T10:51:35Z
dc.date.available2019-08-23T10:51:35Z
dc.date.issued2018-01-19en_US
dc.description.abstract© 2017 American Chemical Society. An efficient C1-difluoromethylation of tetrahydroisoquinolenes was achieved using TMSCF2SPh as a difluoromethylating agent and 2,2,6,6-tetramethylpiperidine-1-oxoammonium tetrafluoroborate (TEMPO+BF4-) as an oxidant. The process provides an access to a variety of C1-difluoro(phenylsulfanyl)methylated tetrahydroisoquinoline adducts in good yields. These adducts were employed as key precursors for preparing fluorinated pyrrolo[2,1-a]isoquinoline and benzo[a]quinolizidines.en_US
dc.identifier.citationJournal of Organic Chemistry. Vol.83, No.2 (2018), 765-782en_US
dc.identifier.doi10.1021/acs.joc.7b02783en_US
dc.identifier.issn15206904en_US
dc.identifier.issn00223263en_US
dc.identifier.other2-s2.0-85040832855en_US
dc.identifier.urihttps://repository.li.mahidol.ac.th/handle/20.500.14594/45512
dc.rightsMahidol Universityen_US
dc.rights.holderSCOPUSen_US
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85040832855&origin=inwarden_US
dc.subjectChemistryen_US
dc.titleOxidative Difluoromethylation of Tetrahydroisoquinolines Using TMSCF<inf>2</inf>SPh: Synthesis of Fluorinated Pyrrolo[2,1-a]isoquinolines and Benzo[a]quinolizidinesen_US
dc.typeArticleen_US
dspace.entity.typePublication
mu.datasource.scopushttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85040832855&origin=inwarden_US

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