Publication: Alterations in capillary permeability in rhesus monkeys with Plasmodium knowlesi infection
Issued Date
1985-12-01
Resource Type
ISSN
00383619
Other identifier(s)
2-s2.0-0022386215
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Southeast Asian Journal of Tropical Medicine and Public Health. Vol.16, No.2 (1985), 285-290
Suggested Citation
S. Areekul Alterations in capillary permeability in rhesus monkeys with Plasmodium knowlesi infection. Southeast Asian Journal of Tropical Medicine and Public Health. Vol.16, No.2 (1985), 285-290. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/30813
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Alterations in capillary permeability in rhesus monkeys with Plasmodium knowlesi infection
Author(s)
Other Contributor(s)
Abstract
The transcapillary escape rate and capillary permeability to albumin were studied in 3 rhesus monkeys throughout the whole course of P. knowlesi infection. The transcapillary escape rates started to increase the first week after infection and were significantly higher than the control values during infection. Plasma volume was found to be increased while plasma albumin concentration decreased which resulted in increased intravascular mass, outflux and clearance of albumin from the intravascular to the extravascular compartments. Increased A(s)/(Δ)X and P(s) during malarial infection indicated thet the increased capillary permeability was due to increased capillary surface area and the increased endothelial permeability. As there was no relationship between increased plasma volume or intravascular mass of albumin and A(s)/(Δ)X or P(s), the increased capillary permeability in these infected monkeys could not be explained by the stretching pore phenomena. As these parameters show a close relationship to the parasitemia, malarial parasites may play a role in causing increased capillary permeability.