Publication: Antioxidant activity and upregulation of antioxidant enzymes of phenolic glycosides from Aquilaria crassna leaves
Issued Date
2017-01-01
Resource Type
ISSN
15559475
1934578X
1934578X
Other identifier(s)
2-s2.0-85035243322
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Natural Product Communications. Vol.12, No.11 (2017), 1691-1694
Suggested Citation
Chonlakan Supasuteekul, Narawat Nuamnaichati, Supachoke Mangmool, Kittisak Likhitwitayawuid, Parkpoom Tengamnuay, Waraporn Putalun, Boonchoo Sritularak Antioxidant activity and upregulation of antioxidant enzymes of phenolic glycosides from Aquilaria crassna leaves. Natural Product Communications. Vol.12, No.11 (2017), 1691-1694. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/41607
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Antioxidant activity and upregulation of antioxidant enzymes of phenolic glycosides from Aquilaria crassna leaves
Other Contributor(s)
Abstract
The leaves of Aquilaria crassna Pierre ex Lecomte (Thymelaeaceae) have been used in the traditional medicine and consumed as a health-promoting tea in several Asian countries. This study investigated the antioxidant activity of three major bioactive constituents of A. crassna leaves, genkwanin 5-O-β- primeveroside (1), iriflophenone 3,5-C-β-D-diglucoside (2) and iriflophenone 3-C-β-D-glucoside (3) using DPPH and superoxide scavenging assays, as well as their effects on induction of mRNA and protein expressions of antioxidant enzymes in HEK-293 cells. The benzophenone glycoside 3 exhibited significant scavenging activity against both types of free radicals and increased the mRNA expression of antioxidant enzymes such as glutathione peroxidase-1, glutathione reductase and heme oxygenase-1 in HEK-293 cells. In addition, all three compounds also increased the protein expression of glutathione peroxidase-1. These findings revealed the effects of these compounds at cellular level, and might be useful for the development of A. crassna leaves as supplements for prevention of oxidative stress.