Publication: Antioxidant activities and protective effects of dendropachol, a new bisbibenzyl compound from dendrobium pachyglossum, on hydrogen peroxide-induced oxidative stress in hacat keratinocytes
Issued Date
2021-02-01
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20763921
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2-s2.0-85100501287
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Mahidol University
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SCOPUS
Bibliographic Citation
Antioxidants. Vol.10, No.2 (2021), 1-16
Suggested Citation
Sakan Warinhomhoun, Chawanphat Muangnoi, Visarut Buranasudja, Wanwimon Mekboonsonglarp, Pornchai Rojsitthisak, Kittisak Likhitwitayawuid, Boonchoo Sritularak Antioxidant activities and protective effects of dendropachol, a new bisbibenzyl compound from dendrobium pachyglossum, on hydrogen peroxide-induced oxidative stress in hacat keratinocytes. Antioxidants. Vol.10, No.2 (2021), 1-16. doi:10.3390/antiox10020252 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/76291
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Title
Antioxidant activities and protective effects of dendropachol, a new bisbibenzyl compound from dendrobium pachyglossum, on hydrogen peroxide-induced oxidative stress in hacat keratinocytes
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Abstract
Five compounds including a new bisbibenzyl named dendropachol (1) and four known compounds (2–5) comprising 4,5-dihydroxy-2,3-dimethoxy-9,10-dihydrophenanthrene (2), gigantol (3), moscatilin (4) and 4,5,4′-trihydroxy-3,3′-dimethoxybibenzyl (5) were isolated from a methanolic extract of Dendrobium pachyglossum (Orchidaceae). The chemical structures of the isolated compounds were characterized by spectroscopic methods. Dendropachol (1) was investigated for its protective effects on hydrogen peroxide (H2O2 )-induced oxidative stress in HaCaT keratinocytes. Compound 1 showed strong free radical scavenging compared to the positive control. For the cytoprotective effect, compound 1 increased the activities of GPx and CAT and the level of GSH but reduced intracellular reactive oxygen species (ROS) generation and accumulation. In addition, compound 1 significantly diminished the expression of p53, Bax, and cytochrome C proteins, decreased the activities of caspase-3 and caspase-9, and increased Bcl-2 protein. The results suggested that compound 1 exhibited antioxidant activities and protective effects in keratinocytes against oxidative stress induced by H2O2 .