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Effects of anticholinergic drugs on cognitive function in older Australians: Results from the AIBL study

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dc.contributor.authorGobhathai Sittironnariten_US
dc.contributor.authorDavid Amesen_US
dc.contributor.authorAshley I. Bushen_US
dc.contributor.authorNoel Fauxen_US
dc.contributor.authorLeon Flickeren_US
dc.contributor.authorJonathan Fosteren_US
dc.contributor.authorSarah Hilmeren_US
dc.contributor.authorNicola T. Lautenschlageren_US
dc.contributor.authorPaul Maruffen_US
dc.contributor.authorColin L. Mastersen_US
dc.contributor.authorRalph N. Martinsen_US
dc.contributor.authorChristopher Roween_US
dc.contributor.authorCassandra Szoekeen_US
dc.contributor.authorKathryn A. Ellisen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherNational Ageing Research Instituteen_US
dc.contributor.otherMental Health Research Institute of Victoriaen_US
dc.contributor.otherDepartment of Pathologyen_US
dc.contributor.otherUniversity of Melbourneen_US
dc.contributor.otherCogState Ltd.en_US
dc.contributor.otherAustin Healthen_US
dc.contributor.otherCommonwealth Scientific and Industrial Research Organizationen_US
dc.contributor.otherWestern Australian Centre for Health and Ageingen_US
dc.contributor.otherUniversity of Western Australiaen_US
dc.contributor.otherHollywood Private Hospitalen_US
dc.contributor.otherEdith Cowan University, Joondalupen_US
dc.contributor.otherThe University of Sydneyen_US
dc.date.accessioned2018-05-03T08:34:10Z
dc.date.available2018-05-03T08:34:10Z
dc.date.issued2011-04-01en_US
dc.description.abstractBackground/Aims: The nature and extent of adverse cognitive effects due to the prescription of anticholinergic drugs in older people with and without dementia is unclear. Methods: We calculated the anticholinergic load (ACL) of medications taken by participants of the Australian Imaging, Biomarkers and Lifestyle (AIBL) study of ageing, a cohort of 211 Alzheimer's disease (AD) patients, 133 mild cognitive impairment (MCI) patients and 768 healthy controls (HC) all aged over 60 years. The association between ACL and cognitive function was examined for each diagnostic group (HC, MCI, AD). Results: A high ACL within the HC group was associated with significantly slower response speeds for the Stroop color and incongruent trials. No other significant relationships between ACL and cognition were noted. Conclusion: In this large cohort, prescribed anticholinergic drugs appeared to have modest effects upon psychomotor speed and executive function, but not on other areas of cognition in healthy older adults. Copyright © 2011 S. Karger AG, Basel.en_US
dc.identifier.citationDementia and Geriatric Cognitive Disorders. Vol.31, No.3 (2011), 173-178en_US
dc.identifier.doi10.1159/000325171en_US
dc.identifier.issn14208008en_US
dc.identifier.other2-s2.0-79952332489en_US
dc.identifier.urihttps://repository.li.mahidol.ac.th/handle/20.500.14594/12584
dc.rightsMahidol Universityen_US
dc.rights.holderSCOPUSen_US
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=79952332489&origin=inwarden_US
dc.subjectMedicineen_US
dc.subjectNeuroscienceen_US
dc.titleEffects of anticholinergic drugs on cognitive function in older Australians: Results from the AIBL studyen_US
dc.typeArticleen_US
dspace.entity.typePublication
mu.datasource.scopushttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=79952332489&origin=inwarden_US

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