Publication: Antibacterial oral sprays from kaffir lime (Citrus hystrix DC.) fruit peel oil and leaf oil and their activities against respiratory tract pathogens
Issued Date
2020-01-01
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ISSN
22254110
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2-s2.0-85084144409
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of Traditional and Complementary Medicine. (2020)
Suggested Citation
Somporn Srifuengfung, Nuntavan Bunyapraphatsara, Veena Satitpatipan, Chanwit Tribuddharat, Varaporn Buraphacheep Junyaprasert, Walla Tungrugsasut, Vimol Srisukh Antibacterial oral sprays from kaffir lime (Citrus hystrix DC.) fruit peel oil and leaf oil and their activities against respiratory tract pathogens. Journal of Traditional and Complementary Medicine. (2020). doi:10.1016/j.jtcme.2019.09.003 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/56309
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Title
Antibacterial oral sprays from kaffir lime (Citrus hystrix DC.) fruit peel oil and leaf oil and their activities against respiratory tract pathogens
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Abstract
© 2019 Center for Food and Biomolecules, National Taiwan University Background and aim: Kaffir lime fruit peel oil and Kaffir lime leaf oil have been reported for their activities against respiratory tract pathogens. The purpose of the study was to develop clear oral sprays to be used as a first-defense oral spray. Experimental procedure: Clear antibacterial oral sprays were prepared and analyzed for their respective active major compounds, using GC-MS. The sprays were tested against a Gr. A streptococcal clinical isolate and 3 standard respiratory tract pathogens, using Broth microdilution method. A 4-month stability test was carried out as well. Results and conclusion: Six clear oral sprays, three formulae composed of Kaffir lime fruit peel oil (6, 10, 13%v/v KLO) and the other three formulae containing Kaffir lime leaf oil (4, 8, 12%v/v KLLO), were developed. The active compounds in KLO were α-terpineol and terpinene-4-ol whereas that in KLLO was citronellal. All oral sprays exhibited antibacterial activity against one Group A streptococcal clinical isolate and three respiratory pathogenic pathogens, Staphylococcus aureus ATCC 29213, Streptococcus pneumoniae ATCC 49619, and Haemophilus influenzae ATCC 49247, among which the strongest activity was against H. influenzae ATCC 49247. The antibacterial activity of all oral sprays remained unchanged in an accelerated stability test, at 4, 30, and 45 °C under 75% relative humidity, throughout the 4-month storage.