Publication: Soluble Moringa oleifera leaf extract reduces intracellular cadmium accumulation and oxidative stress in Saccharomyces cerevisiae
Issued Date
2016-05-01
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ISSN
13474421
13891723
13891723
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2-s2.0-84961209640
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of Bioscience and Bioengineering. Vol.121, No.5 (2016), 543-549
Suggested Citation
Kittikhun Kerdsomboon, Supinda Tatip, Sattawat Kosasih, Choowong Auesukaree Soluble Moringa oleifera leaf extract reduces intracellular cadmium accumulation and oxidative stress in Saccharomyces cerevisiae. Journal of Bioscience and Bioengineering. Vol.121, No.5 (2016), 543-549. doi:10.1016/j.jbiosc.2015.09.013 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/43044
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Title
Soluble Moringa oleifera leaf extract reduces intracellular cadmium accumulation and oxidative stress in Saccharomyces cerevisiae
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Abstract
© 2015 The Society for Biotechnology, Japan. Moringa oleifera leaves are a well-known source of antioxidants and traditionally used for medicinal applications. In the present study, the protective action of soluble M. oleifera leaf extract (MOLE) against cadmium toxicity was investigated in the model eukaryote Saccharomyces cerevisiae. The results showed that this extract exhibited a protective effect against oxidative stress induced by cadmium and H2O2through the reduction of intracellular reactive oxygen species. Interestingly, not only the co-exposure of soluble MOLE with cadmium but also pretreatment of this extract prior to cadmium exposure significantly reduced the cadmium uptake through an inhibition of Fet4p, a low-affinity iron(II) transporter. In addition, the supplementation of soluble MOLE significantly reduced intracellular iron accumulation in a Fet4p-independent manner. Our findings suggest the potential use of soluble extract from M. oleifera leaves as a dietary supplement for protection against cadmium accumulation and oxidative stress.