Publication: Enhancement of dhpn induced hepatocellular, cholangiocellular and pancreatic carcinogenesis by opisthorchis viverrini infestation in syrian golden hamsters
Issued Date
1988-06-01
Resource Type
ISSN
01433334
Other identifier(s)
2-s2.0-0023898433
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Mahidol University
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SCOPUS
Bibliographic Citation
Carcinogenesis. Vol.9, No.6 (1988), 1095-1098
Suggested Citation
Witaya Thamavit, Malcolm A. Moore, Yoshio Hiasa, Nobuyuki Ito Enhancement of dhpn induced hepatocellular, cholangiocellular and pancreatic carcinogenesis by opisthorchis viverrini infestation in syrian golden hamsters. Carcinogenesis. Vol.9, No.6 (1988), 1095-1098. doi:10.1093/carcin/9.6.1095 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/15491
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Title
Enhancement of dhpn induced hepatocellular, cholangiocellular and pancreatic carcinogenesis by opisthorchis viverrini infestation in syrian golden hamsters
Abstract
Infection with 100 Opirthorchis viverrini (OP) metacercariae prior to two injections of dihydroxy-di-n-propyl nitrosamine (DHPN) (1000 mg/kg body weight) brought about significant enhancement of resultant preneoplastic lesion development in Syrian hamster liver and pancreas tissue. Thus combined treatment with carcinogen and parasite was associated with pancreatic atypical (dysplastic) foci, hepatocellular nodules, cholangiofibrosis and cholangiocarcinomas. No such lesions were observed in carcinogen alone, parasite alone or untreated control groups. In addition, parasite induced hyperplastic gall bladder epithelium was found to include areas of putative preneoplastic cells only in the DHPN-OP combined group. The results strongly suggest that pancreatitis and biliary cirrhosis associated with liver fluke infestation are responsible for the observed enhancement of carcinogenesis, and that the resultant increased proliferation plays a major role in tumorigenesis. © 1988 IRL Press Ltd.