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Nitric oxide and aggressive behavior of lung cancer cells

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dc.contributor.authorSudjit Luanpitpongen_US
dc.contributor.authorPithi Chanvorachoteen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherChulalongkorn Universityen_US
dc.date.accessioned2018-11-23T09:50:17Z
dc.date.available2018-11-23T09:50:17Z
dc.date.issued2015-01-01en_US
dc.description.abstractNitric oxide (NO) is an important cell signaling molecule whose level is frequently elevated in many tumors including that of lung. Cellular phenotypes and behaviors are influenced by NO found in proximity to the tumor, namely the tumor microenvironment. In lung cancer, a high level of NO is linked to advanced stage and poor survival of patients. This review describes the promotory role of NO in aggressive behavior of lung cancer cells with a focus on apoptosis and anoikis resistance, cell migration and invasion and cancer stem cells, all of which are key determinants of cancer relapse and metastasis. We specifically address the effects of NO on the modulations of structure, stability, function and activity of key proteins, and discuss how these changes could affect aggressive behavior. Such knowledge will encourage additional experimental and clinical investigations that contribute to the understanding of the molecular basis of cancer pathophysiology which could lead to targeted cancer therapy.en_US
dc.identifier.citationAnticancer Research. Vol.35, No.9 (2015), 4585-4592en_US
dc.identifier.issn02507005en_US
dc.identifier.other2-s2.0-84939628326en_US
dc.identifier.urihttps://repository.li.mahidol.ac.th/handle/20.500.14594/35610
dc.rightsMahidol Universityen_US
dc.rights.holderSCOPUSen_US
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84939628326&origin=inwarden_US
dc.subjectBiochemistry, Genetics and Molecular Biologyen_US
dc.titleNitric oxide and aggressive behavior of lung cancer cellsen_US
dc.typeReviewen_US
dspace.entity.typePublication
mu.datasource.scopushttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84939628326&origin=inwarden_US
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