Publication:
Insights into drug resistance mechanisms in Clostridium difficile

dc.contributor.authorPhurt Harnvoravongchaien_US
dc.contributor.authorMethinee Pipatthanaen_US
dc.contributor.authorSurang Chankhamhaengdechaen_US
dc.contributor.authorTavan Janvilisrien_US
dc.contributor.otherMahidol Universityen_US
dc.date.accessioned2018-12-21T06:53:03Z
dc.date.accessioned2019-03-14T08:02:58Z
dc.date.available2018-12-21T06:53:03Z
dc.date.available2019-03-14T08:02:58Z
dc.date.issued2017-03-03en_US
dc.description.abstract© 2017 The Author(s). The incidence of Clostridium difficile infection has been elevated and becoming common in hospitals worldwide. Although antibiotics usually serve as the primary treatment for bacterial infection including C. difficile infection, limitations and failures have been evident due to drug resistance. Antibiotic resistance in C. difficile has been recognized as one of the most important factors to promote the infection and increase the level of severity and the recurrence rate. Several outbreaks in many countries have been linked to the emergence of hypervirulent drug-resistant strains. This pathogen harbours various mechanisms against the actions of antibiotics. The present study highlights three main drug-resistant strategies in C. difficile including drug inactivation, target modification and efflux pump. Other mechanisms that potentially contribute to drug-resistant traits in this organism are also discussed.en_US
dc.identifier.citationEssays in Biochemistry. Vol.61, No.1 (2017), 81-88en_US
dc.identifier.doi10.1042/EBC20160062en_US
dc.identifier.issn00711365en_US
dc.identifier.other2-s2.0-85015456660en_US
dc.identifier.urihttps://repository.li.mahidol.ac.th/handle/20.500.14594/41951
dc.rightsMahidol Universityen_US
dc.rights.holderSCOPUSen_US
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85015456660&origin=inwarden_US
dc.subjectBiochemistry, Genetics and Molecular Biologyen_US
dc.titleInsights into drug resistance mechanisms in Clostridium difficileen_US
dc.typeReviewen_US
dspace.entity.typePublication
mu.datasource.scopushttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85015456660&origin=inwarden_US

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