Publication: Limonoids from Azadirachta excelsa
Issued Date
1998-04-01
Resource Type
ISSN
00319422
Other identifier(s)
2-s2.0-0032051786
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Phytochemistry. Vol.47, No.7 (1998), 1283-1287
Suggested Citation
Baoliang Cui, Heebyung Chai, Howard L. Constant, Thawatchai Santisuk, Vichai Reutrakul, Christopher W.W. Beecher, Norman R. Farnsworth, Geoffrey A. Cordell, John M. Pezzuto, A. Douglas Kinghorn Limonoids from Azadirachta excelsa. Phytochemistry. Vol.47, No.7 (1998), 1283-1287. doi:10.1016/S0031-9422(97)00711-5 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/18254
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Limonoids from Azadirachta excelsa
Abstract
Activity-directed fractionation of a stem extract of Azadirachta excelsa using KB (human oral epidermoid carcinoma) cells led to the isolation of four meliacin-type limonoids. Two of these constituents were novel, namely, 2,3- dihydronimbolide and 3-deoxymethylnimbidate, and these were purified along with the known compounds, nimbolide and 28-deoxonimbolide. The structures of the new compounds were determined by spectroscopic methods. Nimbolide and 28- deoxonimbolide were broadly cytotoxic when evaluated against a panel of human cancer cell lines, while the two novel compounds were inactive in this regard. The defection of nimbolide and 28-deoxonimbolide as cytotoxic constituents was facilitated by an electrospray LC/MS dereplication procedure.