Publication:
Canadian recommendations for use of methotrexate in patients with rheumatoid arthritis

Issued Date

2010-07-01

Resource Type

Review

ISSN

0315162X

DOI

10.3899/jrheum.090978

Other identifier(s)

2-s2.0-77954445906

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

Journal of Rheumatology. Vol.37, No.7 (2010), 1422-1430

Suggested Citation

Wanruchada Katchamart, Josiane Bourré-Tessier, Timea Donka, Julie Drouin, Gina Rohekar, Vivian P. Bykerk, Boulos Haraoui, Sharon LeClerq, Dianne P. Mosher, Janet E. Pope, Kam Shojania, John Thomson, J. Carter Thorne, Claire Bombardier, Kenneth Blocka, Cathy Elizabeth Flanagan, Paul Davis, Wojciech Olszynski, Vandana Ahluwalia, Michel Zummer, Gilles Boire, Jamie Henderson, Barry Koehler, Philip Baer, Zareen Ahmad, Anne St-Pierre, Martin Cohen, Maysan Abu-Hakima, Majed Khraishi, Elaine Soucy, Jacob Karsh Canadian recommendations for use of methotrexate in patients with rheumatoid arthritis. Journal of Rheumatology. Vol.37, No.7 (2010), 1422-1430. doi:10.3899/jrheum.090978 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/29215

Research Projects

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Thesis

Title

Canadian recommendations for use of methotrexate in patients with rheumatoid arthritis

Author(s)

Wanruchada Katchamart
 Josiane Bourré-Tessier
 Timea Donka
 Julie Drouin
 Gina Rohekar
 Vivian P. Bykerk
 Boulos Haraoui
 Sharon LeClerq
 Dianne P. Mosher
 Janet E. Pope
 Kam Shojania
 John Thomson
 J. Carter Thorne
 Claire Bombardier
 Kenneth Blocka
 Cathy Elizabeth Flanagan
 Paul Davis
 Wojciech Olszynski
 Vandana Ahluwalia
 Michel Zummer
 Gilles Boire
 Jamie Henderson
 Barry Koehler
 Philip Baer
 Zareen Ahmad
 Anne St-Pierre
 Martin Cohen
 Maysan Abu-Hakima
 Majed Khraishi
 Elaine Soucy
 Jacob Karsh

Other Contributor(s)

University of Toronto
 Mahidol University
 Centre Hospitalier de L'Universite de Montreal
 Western University
 University of Calgary
 Dalhousie University
 St. Joseph's Health Care London
 The University of British Columbia
 University of Ottawa, Canada
 The Arthritis Program Research Group Inc.
 Toronto General Research Institute University of Toronto

Abstract

Objective. To develop recommendations for the use of methotrexate (MTX) in patients with rheumatoid arthritis. Methods. Canadian rheumatologists who participated in the international 3e Initiative in Rheumatology (evidence, expertise, exchange) in 2007-2008 formulated 5 unique Canadian questions. A bibliographic team systematically reviewed the relevant literature on these 5 topics. An expert committee consisting of 26 rheumatologists from across Canada was convened, and a set of recommendations was proposed based on the results of systematic reviews combined with expert opinions using a nominal group consensus process. Results. The 5 questions addressed drug interactions, predictors of response, strategies to reduce non-serious side effects, variables to assess clinical response, and incorporating patient preference into decision-making. The systematic review retrieved 93 pertinent articles; this evidence was presented to the expert committee during the interactive workshop. After extensive discussion and voting, a total of 9 recommendations were formulated: 2 on drug interactions, 1 on predictors of response, 2 on strategies to reduce non-serious side effects, 3 on variables to assess clinical response, and 1 on incorporating patient preferences into decision-making. The level of evidence and the strength of recommendations are reported. Agreement among panelists ranged from 85% to 100%. Conclusion. Nine recommendations pertaining to the use of MTX in daily practice were developed using an evidence-based approach followed by expert/physician consensus with high level of agreement. The Journal of Rheumatology Copyright © 2010. All rights reserved.

Keyword(s)

Immunology and Microbiology
 Medicine

Availability

URI

https://repository.li.mahidol.ac.th/handle/20.500.14594/29215

Collections

Scopus 2006-2010