Publication:
Reduced deformability of thalassemic erythrocytes and erythrocytes with abnormal hemoglobins and relation with susceptibility to Plasmodium falciparum invasion

Issued Date

1992-05-01

Resource Type

Article

ISSN

00064971

Other identifier(s)

2-s2.0-0026771882

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

Blood. Vol.79, No.9 (1992), 2460-2463

Suggested Citation

Ahnond Bunyaratvej, Punnee Butthep, Nattaya Sae-Ung, Suthat Fucharoen, Yongyuth Yuthavong Reduced deformability of thalassemic erythrocytes and erythrocytes with abnormal hemoglobins and relation with susceptibility to Plasmodium falciparum invasion. Blood. Vol.79, No.9 (1992), 2460-2463. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/22393

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Title

Reduced deformability of thalassemic erythrocytes and erythrocytes with abnormal hemoglobins and relation with susceptibility to Plasmodium falciparum invasion

Author(s)

Ahnond Bunyaratvej
 Punnee Butthep
 Nattaya Sae-Ung
 Suthat Fucharoen
 Yongyuth Yuthavong

Other Contributor(s)

Mahidol University

Abstract

A number of genetically variant erythrocytes showed decreased deformability of both intact cells and membranes prepared therefrom as measured by laser diffractometry. Erythrocytes associated with minor or no clinical symptoms (eg, α-thalassemia traits, hemoglobin [Hb] E trait, Hb Constant Spring trait), which showed only a minimal decrease in deformability, were, in general, invaded efficiently by the malarial parasite Plasmodium falciparum. Other variant erythrocytes (β-thalassemia/Hb E, homozygous Hb E, homozygous Hb Constant Spring, Hb H, Hb H/Hb Constant Spring) with low deformability showed different degrees of reduction in invasion susceptibility, most of which were less than proportional with deformability decrease. It is concluded that parasite invasion is only weakly related to gross cell deformability, which in turn depends on various factors other than membrane deformability. © 1992 by The American Society of Hematology.

Keyword(s)

Medicine

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URI

https://repository.li.mahidol.ac.th/handle/20.500.14594/22393

Collections

Scopus 1991-2000