Publication: Cryptococcal immune reconstitution inflammatory syndrome after antiretroviral therapy in AIDS patients with cryptococcal meningitis: A prospective multicenter study
Issued Date
2009-09-15
Resource Type
ISSN
10584838
DOI
Other identifier(s)
2-s2.0-70049116229
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Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Clinical Infectious Diseases. Vol.49, No.6 (2009), 931-934
Suggested Citation
Somnuek Sungkanuparph, Scott G. Filler, Ploenchan Chetchotisakd, Peter G. Pappas, Tracy L. Nolen, Weerawat Manosuthi, Thanomsak Anekthananon, Michèle I. Morris, Khuanchai Supparatpinyo, Heather Kopetskie, Amy S. Kendrick, Philip C. Johnson, Jack D. Sobel, Robert A. Larsen Cryptococcal immune reconstitution inflammatory syndrome after antiretroviral therapy in AIDS patients with cryptococcal meningitis: A prospective multicenter study. Clinical Infectious Diseases. Vol.49, No.6 (2009), 931-934. doi:10.1086/605497 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/27933
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Title
Cryptococcal immune reconstitution inflammatory syndrome after antiretroviral therapy in AIDS patients with cryptococcal meningitis: A prospective multicenter study
Other Contributor(s)
Faculty of Medicine, Ramathibodi Hospital, Mahidol University
Mahidol University
Khon Kaen University
Bamrasnaradura Infectious Diseases Institute
Chiang Mai University
Harbor-UCLA Medical Center
University of Southern California
University of Miami Leonard M. Miller School of Medicine
University of Alabama
University of Texas System
Wayne State University
Federal Systems Division
Faculty of Medicine, Thammasat University
Mahidol University
Khon Kaen University
Bamrasnaradura Infectious Diseases Institute
Chiang Mai University
Harbor-UCLA Medical Center
University of Southern California
University of Miami Leonard M. Miller School of Medicine
University of Alabama
University of Texas System
Wayne State University
Federal Systems Division
Faculty of Medicine, Thammasat University
Abstract
A prospective multicenter study of cryptococcal immune reconstitution inflammatory syndrome (IRIS) was conducted as a substudy of the Bacteriology and Mycology Study Group 3-01. Of 101 AIDS patients with cryptococcal meningitis who received highly active antiretroviral therapy (HAART), 13 experienced cryptococcal IRIS. No association between the timing of HAART initiation and the diagnosis of IRIS was identified. Increased baseline serum cryptococcal antigen (CrAg) titer was a risk factor for cryptococcal IRIS. © 2009 by the Infectious Diseases Society of America. All rights reserved.